From structure to sequence: Antibody discovery using cryoEM

One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural and bioinformatic approach to directly assign the heavy and light chains, identify complementarity-determining r...

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Detalles Bibliográficos
Autores principales: Antanasijevic, Aleksandar, Bowman, Charles A., Kirchdoerfer, Robert N., Cottrell, Christopher A., Ozorowski, Gabriel, Upadhyay, Amit A., Cirelli, Kimberly M., Carnathan, Diane G., Enemuo, Chiamaka A., Sewall, Leigh M., Nogal, Bartek, Zhao, Fangzhu, Groschel, Bettina, Schief, William R., Sok, Devin, Silvestri, Guido, Crotty, Shane, Bosinger, Steven E., Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769551/
https://www.ncbi.nlm.nih.gov/pubmed/35044813
http://dx.doi.org/10.1126/sciadv.abk2039

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