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Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA

Vascular endothelium plays a crucial role in vascular homeostasis and tissue fluid balance. To target endothelium for robust genome editing, we developed poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG-b-PLGA) copolymer-based nanoparticle formulated with polyethyleneimine. A...

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Detalles Bibliográficos
Autores principales:	Zhang, Xianming, Jin, Hua, Huang, Xiaojia, Chaurasiya, Birendra, Dong, Daoyin, Shanley, Thomas P., Zhao, You-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769807/ https://www.ncbi.nlm.nih.gov/pubmed/34986352 http://dx.doi.org/10.1016/j.celrep.2021.110196

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