Estimating mouthing exposure to chemicals in children’s products

BACKGROUND: Existing models for estimating children’s exposure to chemicals through mouthing currently depends on the availability of chemical- and material-specific experimental migration rates, only covering a few dozen chemicals. OBJECTIVE: This study objective is hence to develop a mouthing exposure model to predict migration into saliva, mouthing exposure, and related health risk from a wide range of chemical-material combinations in children’s products. METHODS: We collected experimental data on chemical migration from different products into saliva for multiple substance groups and materials, identifying chemical concentration and diffusion coefficient as main properties of influence. To predict migration rates into saliva, we adapted a previously developed migration model for chemicals in food packaging materials. We also developed a regression model based on identified chemical and material properties. RESULTS: Our migration predictions correlate well with experimental data (R(2) = 0.85) and vary widely from 8 × 10(−7) to 32.7 µg/10 cm(2)/min, with plasticizers in PVC showing the highest values. Related mouthing exposure doses vary across chemicals and materials from a median of 0.005 to 253 µg/kg(BW)/d. Finally, we combined exposure estimates with toxicity information to yield hazard quotients and identify chemicals of concern for average and upper bound mouthing behavior scenarios. SIGNIFICANCE: The proposed model can be applied for predicting migration rates for hundreds of chemical-material combinations to support high-throughput screening.