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Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer

BACKGROUND: Although T4b is known to have worse oncologic outcomes, it is unclear whether it truly shows a worse prognosis. This study aims to compare the survival differences between T4a and T4b. METHODS: Patients who were pathologically diagnosed with T3 and T4 colorectal adenocarcinoma from 2010...

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Autores principales: Lim, Ji Ha, Huh, Jung Wook, Lee, Woo Yong, Yun, Seong Hyeon, Kim, Hee Cheol, Cho, Yong Beom, Park, Yoon Ah, Shin, Jung Kyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770269/
https://www.ncbi.nlm.nih.gov/pubmed/35070985
http://dx.doi.org/10.3389/fonc.2021.780684
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author Lim, Ji Ha
Huh, Jung Wook
Lee, Woo Yong
Yun, Seong Hyeon
Kim, Hee Cheol
Cho, Yong Beom
Park, Yoon Ah
Shin, Jung Kyong
author_facet Lim, Ji Ha
Huh, Jung Wook
Lee, Woo Yong
Yun, Seong Hyeon
Kim, Hee Cheol
Cho, Yong Beom
Park, Yoon Ah
Shin, Jung Kyong
author_sort Lim, Ji Ha
collection PubMed
description BACKGROUND: Although T4b is known to have worse oncologic outcomes, it is unclear whether it truly shows a worse prognosis. This study aims to compare the survival differences between T4a and T4b. METHODS: Patients who were pathologically diagnosed with T3 and T4 colorectal adenocarcinoma from 2010 to 2014 were included (T3, n = 1822; T4a, n = 424; T4b, n = 67). Overall survival (OS) and cancer-specific survival (CSS) were compared between T4a and T4b using the Kaplan-Meier method and log-rank test. RESULTS: In stage II, T4a had better OS and CSS than T4b (5-year OS, 89.5% vs. 72.6%; 5-year CSS, 94.4% vs. 81.7%, all p < 0.05), however, in stage III, there were no significant differences in survivals between groups (all p > 0.05). In multivariable analysis, T classification was not an independent risk factor for OS (p > 0.05). However, for CSS, when respectively compared to T3, T4b (HR 3.53, p < 0.001) showed a relatively higher hazard ratio than T4a (HR 2.27, p < 0.001). CONCLUSIONS: T4a showed more favorable OS and CSS than T4b, especially in stage II. Our findings support the current AJCC guidelines, in which T4b is presented as a more advanced stage than T4a.
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spelling pubmed-87702692022-01-21 Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer Lim, Ji Ha Huh, Jung Wook Lee, Woo Yong Yun, Seong Hyeon Kim, Hee Cheol Cho, Yong Beom Park, Yoon Ah Shin, Jung Kyong Front Oncol Oncology BACKGROUND: Although T4b is known to have worse oncologic outcomes, it is unclear whether it truly shows a worse prognosis. This study aims to compare the survival differences between T4a and T4b. METHODS: Patients who were pathologically diagnosed with T3 and T4 colorectal adenocarcinoma from 2010 to 2014 were included (T3, n = 1822; T4a, n = 424; T4b, n = 67). Overall survival (OS) and cancer-specific survival (CSS) were compared between T4a and T4b using the Kaplan-Meier method and log-rank test. RESULTS: In stage II, T4a had better OS and CSS than T4b (5-year OS, 89.5% vs. 72.6%; 5-year CSS, 94.4% vs. 81.7%, all p < 0.05), however, in stage III, there were no significant differences in survivals between groups (all p > 0.05). In multivariable analysis, T classification was not an independent risk factor for OS (p > 0.05). However, for CSS, when respectively compared to T3, T4b (HR 3.53, p < 0.001) showed a relatively higher hazard ratio than T4a (HR 2.27, p < 0.001). CONCLUSIONS: T4a showed more favorable OS and CSS than T4b, especially in stage II. Our findings support the current AJCC guidelines, in which T4b is presented as a more advanced stage than T4a. Frontiers Media S.A. 2022-01-06 /pmc/articles/PMC8770269/ /pubmed/35070985 http://dx.doi.org/10.3389/fonc.2021.780684 Text en Copyright © 2022 Lim, Huh, Lee, Yun, Kim, Cho, Park and Shin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lim, Ji Ha
Huh, Jung Wook
Lee, Woo Yong
Yun, Seong Hyeon
Kim, Hee Cheol
Cho, Yong Beom
Park, Yoon Ah
Shin, Jung Kyong
Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer
title Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer
title_full Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer
title_fullStr Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer
title_full_unstemmed Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer
title_short Comparison of Long-Term Survival Outcomes of T4a and T4b Colorectal Cancer
title_sort comparison of long-term survival outcomes of t4a and t4b colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770269/
https://www.ncbi.nlm.nih.gov/pubmed/35070985
http://dx.doi.org/10.3389/fonc.2021.780684
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