Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo

PURPOSE: Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accumulates and its oxidation upon reperfusion by succinate dehydrogenase (SDH) drives ROS prod...

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Detalles Bibliográficos
Autores principales: Prag, Hiran A., Pala, Laura, Kula-Alwar, Duvaraka, Mulvey, John F., Luping, Du, Beach, Timothy E., Booty, Lee M., Hall, Andrew R., Logan, Angela, Sauchanka, Volha, Caldwell, Stuart T., Robb, Ellen L., James, Andrew M., Xu, Zhelong, Saeb-Parsy, Kourosh, Hartley, Richard C., Murphy, Michael P., Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770414/
https://www.ncbi.nlm.nih.gov/pubmed/32648168
http://dx.doi.org/10.1007/s10557-020-07033-6

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