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A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological Ca(V)3.2 Channelopathies by Promoter-Mediated Transcription Control

Precise genome editing in combination with viral delivery systems provides a valuable tool for neuroscience research. Traditionally, the role of genes in neuronal circuits has been addressed by overexpression or knock-out/knock-down systems. However, those techniques do not manipulate the endogenous...

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Detalles Bibliográficos
Autores principales: Tsortouktzidis, Despina, Tröscher, Anna R., Schulz, Herbert, Opitz, Thoralf, Schoch, Susanne, Becker, Albert J., van Loo, Karen M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770422/
https://www.ncbi.nlm.nih.gov/pubmed/35069110
http://dx.doi.org/10.3389/fnmol.2021.667143