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Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distribute...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770425/ https://www.ncbi.nlm.nih.gov/pubmed/35069281 http://dx.doi.org/10.3389/fpsyt.2021.771147 |
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author | Zhao, Lei Wang, Donglin Xue, Shao-Wei Tan, Zhonglin Luo, Hong Wang, Yan Li, Hanxiaoran Pan, Chenyuan Fu, Sufen Hu, Xiwen Lan, Zhihui Xiao, Yang Kuai, Changxiao |
author_facet | Zhao, Lei Wang, Donglin Xue, Shao-Wei Tan, Zhonglin Luo, Hong Wang, Yan Li, Hanxiaoran Pan, Chenyuan Fu, Sufen Hu, Xiwen Lan, Zhihui Xiao, Yang Kuai, Changxiao |
author_sort | Zhao, Lei |
collection | PubMed |
description | Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distributed brain areas that work together as large-scale brain networks, but it is still unclear whether the dynamic interactions among these emotion networks would be the target of clinical intervention for MDD. Data were collected from 70 MDD patients and 43 sex- and age-matched healthy controls. The dynamic functional connectivity (dFC) between emotion regions was estimated via a sliding-window method based on resting-state functional magnetic resonance imaging (R-fMRI). A k-means clustering method was applied to classify all time windows across all participants into several dFC states reflecting recurring functional interaction patterns among emotion regions over time. The results showed that four dFC states were identified in the emotion networks. Their alterations of state-related occurrence proportion were found in MDD and subsequently normalized following 12-week antidepressant treatment. Baseline strong dFC could predict the reduction rate of Hamilton Depression Rating Scale (HAMD) scores. These findings highlighted the state-dependent reconfiguration of emotion regulation networks in MDD patients owing to antidepressant treatment. |
format | Online Article Text |
id | pubmed-8770425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87704252022-01-21 Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder Zhao, Lei Wang, Donglin Xue, Shao-Wei Tan, Zhonglin Luo, Hong Wang, Yan Li, Hanxiaoran Pan, Chenyuan Fu, Sufen Hu, Xiwen Lan, Zhihui Xiao, Yang Kuai, Changxiao Front Psychiatry Psychiatry Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distributed brain areas that work together as large-scale brain networks, but it is still unclear whether the dynamic interactions among these emotion networks would be the target of clinical intervention for MDD. Data were collected from 70 MDD patients and 43 sex- and age-matched healthy controls. The dynamic functional connectivity (dFC) between emotion regions was estimated via a sliding-window method based on resting-state functional magnetic resonance imaging (R-fMRI). A k-means clustering method was applied to classify all time windows across all participants into several dFC states reflecting recurring functional interaction patterns among emotion regions over time. The results showed that four dFC states were identified in the emotion networks. Their alterations of state-related occurrence proportion were found in MDD and subsequently normalized following 12-week antidepressant treatment. Baseline strong dFC could predict the reduction rate of Hamilton Depression Rating Scale (HAMD) scores. These findings highlighted the state-dependent reconfiguration of emotion regulation networks in MDD patients owing to antidepressant treatment. Frontiers Media S.A. 2022-01-06 /pmc/articles/PMC8770425/ /pubmed/35069281 http://dx.doi.org/10.3389/fpsyt.2021.771147 Text en Copyright © 2022 Zhao, Wang, Xue, Tan, Luo, Wang, Li, Pan, Fu, Hu, Lan, Xiao and Kuai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zhao, Lei Wang, Donglin Xue, Shao-Wei Tan, Zhonglin Luo, Hong Wang, Yan Li, Hanxiaoran Pan, Chenyuan Fu, Sufen Hu, Xiwen Lan, Zhihui Xiao, Yang Kuai, Changxiao Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder |
title | Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder |
title_full | Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder |
title_fullStr | Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder |
title_full_unstemmed | Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder |
title_short | Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder |
title_sort | antidepressant treatment-induced state-dependent reconfiguration of emotion regulation networks in major depressive disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770425/ https://www.ncbi.nlm.nih.gov/pubmed/35069281 http://dx.doi.org/10.3389/fpsyt.2021.771147 |
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