Cargando…

Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder

Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distribute...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Lei, Wang, Donglin, Xue, Shao-Wei, Tan, Zhonglin, Luo, Hong, Wang, Yan, Li, Hanxiaoran, Pan, Chenyuan, Fu, Sufen, Hu, Xiwen, Lan, Zhihui, Xiao, Yang, Kuai, Changxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770425/
https://www.ncbi.nlm.nih.gov/pubmed/35069281
http://dx.doi.org/10.3389/fpsyt.2021.771147
_version_ 1784635369132654592
author Zhao, Lei
Wang, Donglin
Xue, Shao-Wei
Tan, Zhonglin
Luo, Hong
Wang, Yan
Li, Hanxiaoran
Pan, Chenyuan
Fu, Sufen
Hu, Xiwen
Lan, Zhihui
Xiao, Yang
Kuai, Changxiao
author_facet Zhao, Lei
Wang, Donglin
Xue, Shao-Wei
Tan, Zhonglin
Luo, Hong
Wang, Yan
Li, Hanxiaoran
Pan, Chenyuan
Fu, Sufen
Hu, Xiwen
Lan, Zhihui
Xiao, Yang
Kuai, Changxiao
author_sort Zhao, Lei
collection PubMed
description Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distributed brain areas that work together as large-scale brain networks, but it is still unclear whether the dynamic interactions among these emotion networks would be the target of clinical intervention for MDD. Data were collected from 70 MDD patients and 43 sex- and age-matched healthy controls. The dynamic functional connectivity (dFC) between emotion regions was estimated via a sliding-window method based on resting-state functional magnetic resonance imaging (R-fMRI). A k-means clustering method was applied to classify all time windows across all participants into several dFC states reflecting recurring functional interaction patterns among emotion regions over time. The results showed that four dFC states were identified in the emotion networks. Their alterations of state-related occurrence proportion were found in MDD and subsequently normalized following 12-week antidepressant treatment. Baseline strong dFC could predict the reduction rate of Hamilton Depression Rating Scale (HAMD) scores. These findings highlighted the state-dependent reconfiguration of emotion regulation networks in MDD patients owing to antidepressant treatment.
format Online
Article
Text
id pubmed-8770425
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87704252022-01-21 Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder Zhao, Lei Wang, Donglin Xue, Shao-Wei Tan, Zhonglin Luo, Hong Wang, Yan Li, Hanxiaoran Pan, Chenyuan Fu, Sufen Hu, Xiwen Lan, Zhihui Xiao, Yang Kuai, Changxiao Front Psychiatry Psychiatry Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distributed brain areas that work together as large-scale brain networks, but it is still unclear whether the dynamic interactions among these emotion networks would be the target of clinical intervention for MDD. Data were collected from 70 MDD patients and 43 sex- and age-matched healthy controls. The dynamic functional connectivity (dFC) between emotion regions was estimated via a sliding-window method based on resting-state functional magnetic resonance imaging (R-fMRI). A k-means clustering method was applied to classify all time windows across all participants into several dFC states reflecting recurring functional interaction patterns among emotion regions over time. The results showed that four dFC states were identified in the emotion networks. Their alterations of state-related occurrence proportion were found in MDD and subsequently normalized following 12-week antidepressant treatment. Baseline strong dFC could predict the reduction rate of Hamilton Depression Rating Scale (HAMD) scores. These findings highlighted the state-dependent reconfiguration of emotion regulation networks in MDD patients owing to antidepressant treatment. Frontiers Media S.A. 2022-01-06 /pmc/articles/PMC8770425/ /pubmed/35069281 http://dx.doi.org/10.3389/fpsyt.2021.771147 Text en Copyright © 2022 Zhao, Wang, Xue, Tan, Luo, Wang, Li, Pan, Fu, Hu, Lan, Xiao and Kuai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhao, Lei
Wang, Donglin
Xue, Shao-Wei
Tan, Zhonglin
Luo, Hong
Wang, Yan
Li, Hanxiaoran
Pan, Chenyuan
Fu, Sufen
Hu, Xiwen
Lan, Zhihui
Xiao, Yang
Kuai, Changxiao
Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
title Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
title_full Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
title_fullStr Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
title_full_unstemmed Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
title_short Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder
title_sort antidepressant treatment-induced state-dependent reconfiguration of emotion regulation networks in major depressive disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770425/
https://www.ncbi.nlm.nih.gov/pubmed/35069281
http://dx.doi.org/10.3389/fpsyt.2021.771147
work_keys_str_mv AT zhaolei antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT wangdonglin antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT xueshaowei antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT tanzhonglin antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT luohong antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT wangyan antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT lihanxiaoran antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT panchenyuan antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT fusufen antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT huxiwen antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT lanzhihui antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT xiaoyang antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder
AT kuaichangxiao antidepressanttreatmentinducedstatedependentreconfigurationofemotionregulationnetworksinmajordepressivedisorder