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Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants

Micromotion-induced stress remains one of the main determinants of life of intracortical implants. This is due to high stress leading to tissue injury, which in turn leads to an immune response coupled with a significant reduction in the nearby neural population and subsequent isolation of the impla...

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Autores principales: Al Abed, Ali, Amatoury, Jason, Khraiche, Massoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770436/
https://www.ncbi.nlm.nih.gov/pubmed/35069092
http://dx.doi.org/10.3389/fnins.2021.727715
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author Al Abed, Ali
Amatoury, Jason
Khraiche, Massoud
author_facet Al Abed, Ali
Amatoury, Jason
Khraiche, Massoud
author_sort Al Abed, Ali
collection PubMed
description Micromotion-induced stress remains one of the main determinants of life of intracortical implants. This is due to high stress leading to tissue injury, which in turn leads to an immune response coupled with a significant reduction in the nearby neural population and subsequent isolation of the implant. In this work, we develop a finite element model of the intracortical probe-tissue interface to study the effect of implant micromotion, implant thickness, and material properties on the strain levels induced in brain tissue. Our results showed that for stiff implants, the strain magnitude is dependent on the magnitude of the motion, where a micromotion increase from 1 to 10 μm induced an increase in the strain by an order of magnitude. For higher displacement over 10 μm, the change in the strain was relatively smaller. We also showed that displacement magnitude has no impact on the location of maximum strain and addressed the conflicting results in the literature. Further, we explored the effect of different probe materials [i.e., silicon, polyimide (PI), and polyvinyl acetate nanocomposite (PVAc-NC)] on the magnitude, location, and distribution of strain. Finally, we showed that strain distribution across cortical implants was in line with published results on the size of the typical glial response to the neural probe, further reaffirming that strain can be a precursor to the glial response.
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spelling pubmed-87704362022-01-21 Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants Al Abed, Ali Amatoury, Jason Khraiche, Massoud Front Neurosci Neuroscience Micromotion-induced stress remains one of the main determinants of life of intracortical implants. This is due to high stress leading to tissue injury, which in turn leads to an immune response coupled with a significant reduction in the nearby neural population and subsequent isolation of the implant. In this work, we develop a finite element model of the intracortical probe-tissue interface to study the effect of implant micromotion, implant thickness, and material properties on the strain levels induced in brain tissue. Our results showed that for stiff implants, the strain magnitude is dependent on the magnitude of the motion, where a micromotion increase from 1 to 10 μm induced an increase in the strain by an order of magnitude. For higher displacement over 10 μm, the change in the strain was relatively smaller. We also showed that displacement magnitude has no impact on the location of maximum strain and addressed the conflicting results in the literature. Further, we explored the effect of different probe materials [i.e., silicon, polyimide (PI), and polyvinyl acetate nanocomposite (PVAc-NC)] on the magnitude, location, and distribution of strain. Finally, we showed that strain distribution across cortical implants was in line with published results on the size of the typical glial response to the neural probe, further reaffirming that strain can be a precursor to the glial response. Frontiers Media S.A. 2022-01-06 /pmc/articles/PMC8770436/ /pubmed/35069092 http://dx.doi.org/10.3389/fnins.2021.727715 Text en Copyright © 2022 Al Abed, Amatoury and Khraiche. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Al Abed, Ali
Amatoury, Jason
Khraiche, Massoud
Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants
title Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants
title_full Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants
title_fullStr Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants
title_full_unstemmed Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants
title_short Finite Element Modeling of Magnitude and Location of Brain Micromotion Induced Strain for Intracortical Implants
title_sort finite element modeling of magnitude and location of brain micromotion induced strain for intracortical implants
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770436/
https://www.ncbi.nlm.nih.gov/pubmed/35069092
http://dx.doi.org/10.3389/fnins.2021.727715
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