Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study

Non-β-hemolytic streptococci (NBHS) cause infective endocarditis (IE) and a short blood culture time to positivity (TTP) is associated with risk of IE in bacteremia with other pathogens. In this retrospective population-based cohort study, we investigate if TTP is associated to IE or mortality. Of 2...

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Autores principales: Krus, David, Kahn, Fredrik, Nilson, Bo, Sunnerhagen, Torgny, Rasmussen, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770443/
https://www.ncbi.nlm.nih.gov/pubmed/34654986
http://dx.doi.org/10.1007/s10096-021-04339-7
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author Krus, David
Kahn, Fredrik
Nilson, Bo
Sunnerhagen, Torgny
Rasmussen, Magnus
author_facet Krus, David
Kahn, Fredrik
Nilson, Bo
Sunnerhagen, Torgny
Rasmussen, Magnus
author_sort Krus, David
collection PubMed
description Non-β-hemolytic streptococci (NBHS) cause infective endocarditis (IE) and a short blood culture time to positivity (TTP) is associated with risk of IE in bacteremia with other pathogens. In this retrospective population-based cohort study, we investigate if TTP is associated to IE or mortality. Of 263 episodes with NBHS bacteremia, 28 represented IE and the median TTP did not differ significantly between episodes with IE (15 h) and non-IE (15 h) (p=0.51). TTP was similar among those who survived and those who died within 30 days. However, TTP significantly differed when comparing the different streptococcal groups (p<0.001). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04339-7.
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spelling pubmed-87704432022-02-02 Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study Krus, David Kahn, Fredrik Nilson, Bo Sunnerhagen, Torgny Rasmussen, Magnus Eur J Clin Microbiol Infect Dis Brief Report Non-β-hemolytic streptococci (NBHS) cause infective endocarditis (IE) and a short blood culture time to positivity (TTP) is associated with risk of IE in bacteremia with other pathogens. In this retrospective population-based cohort study, we investigate if TTP is associated to IE or mortality. Of 263 episodes with NBHS bacteremia, 28 represented IE and the median TTP did not differ significantly between episodes with IE (15 h) and non-IE (15 h) (p=0.51). TTP was similar among those who survived and those who died within 30 days. However, TTP significantly differed when comparing the different streptococcal groups (p<0.001). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04339-7. Springer Berlin Heidelberg 2021-10-16 2022 /pmc/articles/PMC8770443/ /pubmed/34654986 http://dx.doi.org/10.1007/s10096-021-04339-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Krus, David
Kahn, Fredrik
Nilson, Bo
Sunnerhagen, Torgny
Rasmussen, Magnus
Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
title Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
title_full Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
title_fullStr Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
title_full_unstemmed Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
title_short Blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
title_sort blood culture time to positivity in non-β-hemolytic streptococcal bacteremia as a predictor of infective endocarditis—a retrospective cohort study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770443/
https://www.ncbi.nlm.nih.gov/pubmed/34654986
http://dx.doi.org/10.1007/s10096-021-04339-7
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