Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that IL-37 transgenic (IL-37tg) mice were highly susceptible to colitis-associa...

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Detalles Bibliográficos
Autores principales: Wang, Zhen, Zeng, Fan-lian, Hu, Ya-wen, Wang, Xiao-yan, Zhao, Fu-lei, Zhou, Pei, Hu, Jing, Xiao, Yuan-yuan, Hu, Zhong-lan, Guo, Ming-feng, Wei, Xiao-qiong, Liu, Xiao, Huang, Nong-yu, Zhang, Jun, Chen, Shu-wen, Cheng, Juan, Zheng, Hua-ping, Zhou, Hong, Zhao, Qi-xiang, Zhang, Chen, Hao, Yan, Zou, Song, Gui, Yi-yue, Yu, Jia-dong, Gu, Lin-na, Yue, Cheng-cheng, Zhang, Hao-zhou, Wu, Wen-ling, Zhou, Yi-fan, Zhou, Xi-kun, Shen, Guo-bo, Teng, Xiu, Li, Jiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770466/
https://www.ncbi.nlm.nih.gov/pubmed/35046386
http://dx.doi.org/10.1038/s41392-021-00820-z

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