Advantages of multi-arm non-randomised sequentially allocated cohort designs for Phase II oncology trials

BACKGROUND: Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment. METHODS: Motivated by the WIRE trial in renal cell ca...

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Detalles Bibliográficos
Autores principales: Mossop, Helen, Grayling, Michael J., Gallagher, Ferdia A., Welsh, Sarah J., Stewart, Grant D., Wason, James M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770479/
https://www.ncbi.nlm.nih.gov/pubmed/34750494
http://dx.doi.org/10.1038/s41416-021-01613-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770479/
https://www.ncbi.nlm.nih.gov/pubmed/34750494
http://dx.doi.org/10.1038/s41416-021-01613-5

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