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Advantages of multi-arm non-randomised sequentially allocated cohort designs for Phase II oncology trials
BACKGROUND: Efficient trial designs are required to prioritise promising drugs within Phase II trials. Adaptive designs are examples of such designs, but their efficiency is reduced if there is a delay in assessing patient responses to treatment. METHODS: Motivated by the WIRE trial in renal cell ca...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770479/ https://www.ncbi.nlm.nih.gov/pubmed/34750494 http://dx.doi.org/10.1038/s41416-021-01613-5 |