Crystal structure of the α(1B)-adrenergic receptor reveals molecular determinants of selective ligand recognition

α-adrenergic receptors (αARs) are G protein-coupled receptors that regulate vital functions of the cardiovascular and nervous systems. The therapeutic potential of αARs, however, is largely unexploited and hampered by the scarcity of subtype-selective ligands. Moreover, several aminergic drugs eithe...

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Detalles Bibliográficos
Autores principales: Deluigi, Mattia, Morstein, Lena, Schuster, Matthias, Klenk, Christoph, Merklinger, Lisa, Cridge, Riley R., de Zhang, Lazarus A., Klipp, Alexander, Vacca, Santiago, Vaid, Tasneem M., Mittl, Peer R. E., Egloff, Pascal, Eberle, Stefanie A., Zerbe, Oliver, Chalmers, David K., Scott, Daniel J., Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770593/
https://www.ncbi.nlm.nih.gov/pubmed/35046410
http://dx.doi.org/10.1038/s41467-021-27911-3

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