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Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve
INTRODUCTION: This study reports the outcomes of fluocinolone acetonide intravitreal implant (FAc, Iluvien(®), SIFI, Italy) in patients affected by macular edema secondary to chronic non-infectious uveitis of the posterior segment (NIU-PS). METHODS: This was a retrospective study of patients with NI...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770757/ https://www.ncbi.nlm.nih.gov/pubmed/34787827 http://dx.doi.org/10.1007/s40123-021-00426-2 |
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author | Battista, Marco Starace, Vincenzo Cicinelli, Maria Vittoria Capone, Luigi Marchese, Alessandro Modorati, Giulio Bandello, Francesco Miserocchi, Elisabetta |
author_facet | Battista, Marco Starace, Vincenzo Cicinelli, Maria Vittoria Capone, Luigi Marchese, Alessandro Modorati, Giulio Bandello, Francesco Miserocchi, Elisabetta |
author_sort | Battista, Marco |
collection | PubMed |
description | INTRODUCTION: This study reports the outcomes of fluocinolone acetonide intravitreal implant (FAc, Iluvien(®), SIFI, Italy) in patients affected by macular edema secondary to chronic non-infectious uveitis of the posterior segment (NIU-PS). METHODS: This was a retrospective study of patients with NIU-PS and macular thickening undergoing FAc implant at San Raffaele Hospital (Milan, Italy). Clinical data, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), and central macular thickness (CMT), were collected at the time of FAc administration (baseline) and at 1, 6, and 12 months. The area under the curve (AUC) of the BCVA (AUC(BCVA)) and CMT (AUC(CMT)) was correlated with baseline factors; β estimates and 95% confidence interval (CI) are provided. RESULTS: Ten eyes of seven patients (60 ± 12 years; 4 male, 57%) were included. The BCVA significantly improved from month 6 (p = 0.03). The CMT improved from month 1 and was persistently lower than baseline until month 12 (p < 0.001). The AUC(BCVA) correlated with baseline BCVA (β = 2.5 logMAR; 95% CI 1.59–3.41; p < 0.001), while the mean AUC(CMT) positively correlated with the baseline CMT (β = 2.1 μm; 95% CI 0.41–3.80; p = 0.02). No adverse events were recorded over 1 year. CONCLUSIONS: Better visual acuity at the time of FAc administration was associated with better visual function after FAc. Less severe macular edema correlated with better anatomic response. The FAc implant was a safe option for resolving macular edema secondary to NIU-PS. |
format | Online Article Text |
id | pubmed-8770757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-87707572022-02-02 Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve Battista, Marco Starace, Vincenzo Cicinelli, Maria Vittoria Capone, Luigi Marchese, Alessandro Modorati, Giulio Bandello, Francesco Miserocchi, Elisabetta Ophthalmol Ther Original Research INTRODUCTION: This study reports the outcomes of fluocinolone acetonide intravitreal implant (FAc, Iluvien(®), SIFI, Italy) in patients affected by macular edema secondary to chronic non-infectious uveitis of the posterior segment (NIU-PS). METHODS: This was a retrospective study of patients with NIU-PS and macular thickening undergoing FAc implant at San Raffaele Hospital (Milan, Italy). Clinical data, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), and central macular thickness (CMT), were collected at the time of FAc administration (baseline) and at 1, 6, and 12 months. The area under the curve (AUC) of the BCVA (AUC(BCVA)) and CMT (AUC(CMT)) was correlated with baseline factors; β estimates and 95% confidence interval (CI) are provided. RESULTS: Ten eyes of seven patients (60 ± 12 years; 4 male, 57%) were included. The BCVA significantly improved from month 6 (p = 0.03). The CMT improved from month 1 and was persistently lower than baseline until month 12 (p < 0.001). The AUC(BCVA) correlated with baseline BCVA (β = 2.5 logMAR; 95% CI 1.59–3.41; p < 0.001), while the mean AUC(CMT) positively correlated with the baseline CMT (β = 2.1 μm; 95% CI 0.41–3.80; p = 0.02). No adverse events were recorded over 1 year. CONCLUSIONS: Better visual acuity at the time of FAc administration was associated with better visual function after FAc. Less severe macular edema correlated with better anatomic response. The FAc implant was a safe option for resolving macular edema secondary to NIU-PS. Springer Healthcare 2021-11-17 2022-02 /pmc/articles/PMC8770757/ /pubmed/34787827 http://dx.doi.org/10.1007/s40123-021-00426-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Battista, Marco Starace, Vincenzo Cicinelli, Maria Vittoria Capone, Luigi Marchese, Alessandro Modorati, Giulio Bandello, Francesco Miserocchi, Elisabetta Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve |
title | Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve |
title_full | Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve |
title_fullStr | Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve |
title_full_unstemmed | Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve |
title_short | Efficacy of 0.19 mg Fluocinolone Acetonide Implant in Non-infectious Posterior Uveitis Evaluated as Area Under the Curve |
title_sort | efficacy of 0.19 mg fluocinolone acetonide implant in non-infectious posterior uveitis evaluated as area under the curve |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770757/ https://www.ncbi.nlm.nih.gov/pubmed/34787827 http://dx.doi.org/10.1007/s40123-021-00426-2 |
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