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A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal...

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Autores principales: Morrell, J. M., Rocha, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770823/
https://www.ncbi.nlm.nih.gov/pubmed/35071389
http://dx.doi.org/10.3389/fvets.2021.799619
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author Morrell, J. M.
Rocha, A.
author_facet Morrell, J. M.
Rocha, A.
author_sort Morrell, J. M.
collection PubMed
description One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal plasma proteins, spermatozoa, bacteria and debris initiate an inflammatory response; the resulting fluid and neutrophils are then cleared from the uterus along with the debris. However, in some mares, the response is prolonged or exaggerated, with much fluid formation and neutrophil infiltration leading to acute endometritis. A bacterial cause has been implicated, although in some cases no pathogenic organisms can be isolated on culture. It has been postulated that any one of a variety of bacteria could be involved, or dysbiosis of the uterine microbiome could be responsible. Repeated episodes of acute endometritis may lead to the pathology associated with chronic endometritis, with mucociliary dysfunction, vascular degeneration and plasma cell infiltration. This review examines the information that is currently available about equine endometritis, particularly about the role of the inseminate in the uterus, and its current treatment. There are some promising lines of research into treatment or prevention that may help to resolve the issue.
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spelling pubmed-87708232022-01-21 A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State Morrell, J. M. Rocha, A. Front Vet Sci Veterinary Science One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal plasma proteins, spermatozoa, bacteria and debris initiate an inflammatory response; the resulting fluid and neutrophils are then cleared from the uterus along with the debris. However, in some mares, the response is prolonged or exaggerated, with much fluid formation and neutrophil infiltration leading to acute endometritis. A bacterial cause has been implicated, although in some cases no pathogenic organisms can be isolated on culture. It has been postulated that any one of a variety of bacteria could be involved, or dysbiosis of the uterine microbiome could be responsible. Repeated episodes of acute endometritis may lead to the pathology associated with chronic endometritis, with mucociliary dysfunction, vascular degeneration and plasma cell infiltration. This review examines the information that is currently available about equine endometritis, particularly about the role of the inseminate in the uterus, and its current treatment. There are some promising lines of research into treatment or prevention that may help to resolve the issue. Frontiers Media S.A. 2022-01-06 /pmc/articles/PMC8770823/ /pubmed/35071389 http://dx.doi.org/10.3389/fvets.2021.799619 Text en Copyright © 2022 Morrell and Rocha. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Morrell, J. M.
Rocha, A.
A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State
title A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State
title_full A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State
title_fullStr A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State
title_full_unstemmed A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State
title_short A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State
title_sort novel approach to minimising acute equine endometritis that may help to prevent the development of the chronic state
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770823/
https://www.ncbi.nlm.nih.gov/pubmed/35071389
http://dx.doi.org/10.3389/fvets.2021.799619
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