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High Level of Aristolochic Acid Detected With a Unique Genomic Landscape Predicts Early UTUC Onset After Renal Transplantation in Taiwan

BACKGROUND: The unusual high dialysis prevalence and upper urinary tract urothelial carcinoma (UTUC) incidence in Taiwan may attribute to aristolochic acid (AA), which is nephrotoxic and carcinogenic, exposure. AA can cause a unique mutagenic pattern showing A:T to T:A transversions (mutational Sign...

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Detalles Bibliográficos
Autores principales:	Lai, Hong-Yue, Wu, Li-Ching, Kong, Po-Hsin, Tsai, Hsin-Hwa, Chen, Yen-Ta, Cheng, Yuan-Tso, Luo, Hao-Lun, Li, Chien-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770835/ https://www.ncbi.nlm.nih.gov/pubmed/35071023 http://dx.doi.org/10.3389/fonc.2021.828314

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