Tlr2/4‐Mediated Hyperinflammation Promotes Cherubism‐Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice

Cherubism (CBM), characterized by expansile jawbones with multilocular fibrocystic lesions, is caused by gain‐of‐function mutations in SH3 domain‐binding protein 2 (SH3BP2; mouse orthologue Sh3bp2). Loss of jawbone and dental integrity significantly decrease the quality of life for affected children...

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Detalles Bibliográficos
Autores principales: Fujii, Yasuyuki, Monteiro, Nelson, Sah, Shyam Kishor, Javaheri, Homan, Ueki, Yasuyoshi, Fan, Zhichao, Reichenberger, Ernst J, Chen, I‐Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771001/
https://www.ncbi.nlm.nih.gov/pubmed/35079675
http://dx.doi.org/10.1002/jbm4.10562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771001/
https://www.ncbi.nlm.nih.gov/pubmed/35079675
http://dx.doi.org/10.1002/jbm4.10562

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