Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan

Multi-targeted tyrosine kinase inhibitor (TKI) pazopanib approved for the treatment of advanced soft tissue sarcoma (STS) has prolonged the estimated survival times and quality of life of patients. However, several adverse effects associated predominantly with the inhibition of the vascular endothel...

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Autores principales: Pereira, Melvika, Shivdasani, Divya, Singh, Natasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771063/
https://www.ncbi.nlm.nih.gov/pubmed/35125763
http://dx.doi.org/10.4103/ijnm.ijnm_49_21
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author Pereira, Melvika
Shivdasani, Divya
Singh, Natasha
author_facet Pereira, Melvika
Shivdasani, Divya
Singh, Natasha
author_sort Pereira, Melvika
collection PubMed
description Multi-targeted tyrosine kinase inhibitor (TKI) pazopanib approved for the treatment of advanced soft tissue sarcoma (STS) has prolonged the estimated survival times and quality of life of patients. However, several adverse effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One such rare adverse event with the use of pazopanib is acute pancreatitis. We present a case of asymptomatic necrotizing pancreatitis induced by pazopanib treatment for metastatic STS detected on (18)F-FDG PET-CT imaging.
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spelling pubmed-87710632022-02-03 Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan Pereira, Melvika Shivdasani, Divya Singh, Natasha Indian J Nucl Med Case Report Multi-targeted tyrosine kinase inhibitor (TKI) pazopanib approved for the treatment of advanced soft tissue sarcoma (STS) has prolonged the estimated survival times and quality of life of patients. However, several adverse effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One such rare adverse event with the use of pazopanib is acute pancreatitis. We present a case of asymptomatic necrotizing pancreatitis induced by pazopanib treatment for metastatic STS detected on (18)F-FDG PET-CT imaging. Wolters Kluwer - Medknow 2021 2021-12-15 /pmc/articles/PMC8771063/ /pubmed/35125763 http://dx.doi.org/10.4103/ijnm.ijnm_49_21 Text en Copyright: © 2021 Indian Journal of Nuclear Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Pereira, Melvika
Shivdasani, Divya
Singh, Natasha
Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan
title Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan
title_full Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan
title_fullStr Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan
title_full_unstemmed Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan
title_short Pazopanib-Induced Asymptomatic Necrotizing Pancreatitis Diagnosed on (18)F-FDG PET-CT Scan
title_sort pazopanib-induced asymptomatic necrotizing pancreatitis diagnosed on (18)f-fdg pet-ct scan
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771063/
https://www.ncbi.nlm.nih.gov/pubmed/35125763
http://dx.doi.org/10.4103/ijnm.ijnm_49_21
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