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Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology
AIM: This study aims to study the clinical-diagnostic relevance of incidental breast uptake (“incidentaloma”) on 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan performed for other indications and to correlate it with radiological imaging and histo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771069/ https://www.ncbi.nlm.nih.gov/pubmed/35125756 http://dx.doi.org/10.4103/ijnm.ijnm_52_21 |
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author | Panareo, Stefano Urso, Luca Nieri, Alberto Caracciolo, Matteo Valpiani, Giorgia Torricelli, Pietro Frassoldati, Antonio Cittanti, Corrado Rollo, Marco Bartolomei, Mirco |
author_facet | Panareo, Stefano Urso, Luca Nieri, Alberto Caracciolo, Matteo Valpiani, Giorgia Torricelli, Pietro Frassoldati, Antonio Cittanti, Corrado Rollo, Marco Bartolomei, Mirco |
author_sort | Panareo, Stefano |
collection | PubMed |
description | AIM: This study aims to study the clinical-diagnostic relevance of incidental breast uptake (“incidentaloma”) on 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan performed for other indications and to correlate it with radiological imaging and histopathology. MATERIALS AND METHODS: We retrospectively evaluated 3675 FDG-PET scans, identifying 43 patients with breast “incidentaloma.” Thirty of these findings were further investigated with clinical examination, mammography (MMX), UltraSound (US) and/or magnetic resonance (MR). Cases suspected for malignancy underwent US-guided macro-biopsy (USMB) or MR-guided biopsy. Correlations between FDG-PET, radiology findings, age, and histopathology were evaluated. RESULTS: patients who performed both US and MMX were 19. Ten consequently underwent USMB, one MR-guided biopsy, the remaining 8 were not further investigated. Nine patients had a diagnosis of malignancy. Among 11 patients who performed only US and consequently, USMB 6 had a diagnosis of malignancy. Histopathology of the 22 patients with both morphological and glucometabolic alterations showed different types of benign or malignant neoplasia, with a cumulative 68.2% incidence of malignancy. Seven lesions showed a SUV(max) >2.5, while the remaining 15 a SUV(max) <2.5. There was no statistically significant correlation between SUV(max) and histology, therefore SUV(max) parameter should not be used to discriminate between benign and malignant findings. No significant correlation between patient age and tumor characterization was found. CONCLUSIONS: incidental mammary uptake during an FDG-PET scan may represent a clue suggesting to investigate PET findings. In this subset of patients, early diagnosis may lead to a change in clinical management with a favorable impact on prognosis and a significant reduction in healthcare costs. |
format | Online Article Text |
id | pubmed-8771069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-87710692022-02-03 Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology Panareo, Stefano Urso, Luca Nieri, Alberto Caracciolo, Matteo Valpiani, Giorgia Torricelli, Pietro Frassoldati, Antonio Cittanti, Corrado Rollo, Marco Bartolomei, Mirco Indian J Nucl Med Original Article AIM: This study aims to study the clinical-diagnostic relevance of incidental breast uptake (“incidentaloma”) on 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan performed for other indications and to correlate it with radiological imaging and histopathology. MATERIALS AND METHODS: We retrospectively evaluated 3675 FDG-PET scans, identifying 43 patients with breast “incidentaloma.” Thirty of these findings were further investigated with clinical examination, mammography (MMX), UltraSound (US) and/or magnetic resonance (MR). Cases suspected for malignancy underwent US-guided macro-biopsy (USMB) or MR-guided biopsy. Correlations between FDG-PET, radiology findings, age, and histopathology were evaluated. RESULTS: patients who performed both US and MMX were 19. Ten consequently underwent USMB, one MR-guided biopsy, the remaining 8 were not further investigated. Nine patients had a diagnosis of malignancy. Among 11 patients who performed only US and consequently, USMB 6 had a diagnosis of malignancy. Histopathology of the 22 patients with both morphological and glucometabolic alterations showed different types of benign or malignant neoplasia, with a cumulative 68.2% incidence of malignancy. Seven lesions showed a SUV(max) >2.5, while the remaining 15 a SUV(max) <2.5. There was no statistically significant correlation between SUV(max) and histology, therefore SUV(max) parameter should not be used to discriminate between benign and malignant findings. No significant correlation between patient age and tumor characterization was found. CONCLUSIONS: incidental mammary uptake during an FDG-PET scan may represent a clue suggesting to investigate PET findings. In this subset of patients, early diagnosis may lead to a change in clinical management with a favorable impact on prognosis and a significant reduction in healthcare costs. Wolters Kluwer - Medknow 2021 2021-12-15 /pmc/articles/PMC8771069/ /pubmed/35125756 http://dx.doi.org/10.4103/ijnm.ijnm_52_21 Text en Copyright: © 2021 Indian Journal of Nuclear Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Panareo, Stefano Urso, Luca Nieri, Alberto Caracciolo, Matteo Valpiani, Giorgia Torricelli, Pietro Frassoldati, Antonio Cittanti, Corrado Rollo, Marco Bartolomei, Mirco Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology |
title | Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology |
title_full | Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology |
title_fullStr | Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology |
title_full_unstemmed | Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology |
title_short | Clinical-Diagnostic Relevance of Breast “Incidentaloma” Detected During 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography: Correlation with Radiological Imaging and Histopathology |
title_sort | clinical-diagnostic relevance of breast “incidentaloma” detected during 18f-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography: correlation with radiological imaging and histopathology |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771069/ https://www.ncbi.nlm.nih.gov/pubmed/35125756 http://dx.doi.org/10.4103/ijnm.ijnm_52_21 |
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