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A novel viewpoint in glaucoma therapeutics: enriched environment
Glaucoma is one of the world's most frequent visual impairment causes and leads to selective damage to retinal ganglion cells and their axons. Despite glaucoma's most accepted risk factor is increased intraocular pressure (IOP), the mechanisms behind the disease have not been fully elucida...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771091/ https://www.ncbi.nlm.nih.gov/pubmed/34916414 http://dx.doi.org/10.4103/1673-5374.330594 |
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author | González Fleitas, María F. Dorfman, Damián Rosenstein, Ruth E. |
author_facet | González Fleitas, María F. Dorfman, Damián Rosenstein, Ruth E. |
author_sort | González Fleitas, María F. |
collection | PubMed |
description | Glaucoma is one of the world's most frequent visual impairment causes and leads to selective damage to retinal ganglion cells and their axons. Despite glaucoma's most accepted risk factor is increased intraocular pressure (IOP), the mechanisms behind the disease have not been fully elucidated. To date, IOP lowering remains the gold standard; however, glaucoma patients may still lose vision regardless of effective IOP management. Therefore, the exclusive IOP control apparently is not enough to stop the disease progression, and developing new resources to protect the retina and optic nerve against glaucoma is a goal of vast clinical importance. Besides pharmacological treatments, environmental conditions have been shown to prevent neurodegeneration in the central nervous system. In this review, we discuss current concepts on key pathogenic mechanisms involved in glaucoma, the effect of enriched environment on these mechanisms in different experimental models, as well as recent evidence supporting the preventive and therapeutic effect of enriched environment exposure against experimental glaucomatous damage. Finally, we postulate that stimulating vision may become a non-invasive and rehabilitative therapy that could be eventually translated to the human disease, preventing glaucoma-induced terrible sequelae resulting in permanent visual disability. |
format | Online Article Text |
id | pubmed-8771091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-87710912022-02-03 A novel viewpoint in glaucoma therapeutics: enriched environment González Fleitas, María F. Dorfman, Damián Rosenstein, Ruth E. Neural Regen Res Review Glaucoma is one of the world's most frequent visual impairment causes and leads to selective damage to retinal ganglion cells and their axons. Despite glaucoma's most accepted risk factor is increased intraocular pressure (IOP), the mechanisms behind the disease have not been fully elucidated. To date, IOP lowering remains the gold standard; however, glaucoma patients may still lose vision regardless of effective IOP management. Therefore, the exclusive IOP control apparently is not enough to stop the disease progression, and developing new resources to protect the retina and optic nerve against glaucoma is a goal of vast clinical importance. Besides pharmacological treatments, environmental conditions have been shown to prevent neurodegeneration in the central nervous system. In this review, we discuss current concepts on key pathogenic mechanisms involved in glaucoma, the effect of enriched environment on these mechanisms in different experimental models, as well as recent evidence supporting the preventive and therapeutic effect of enriched environment exposure against experimental glaucomatous damage. Finally, we postulate that stimulating vision may become a non-invasive and rehabilitative therapy that could be eventually translated to the human disease, preventing glaucoma-induced terrible sequelae resulting in permanent visual disability. Wolters Kluwer - Medknow 2021-12-10 /pmc/articles/PMC8771091/ /pubmed/34916414 http://dx.doi.org/10.4103/1673-5374.330594 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review González Fleitas, María F. Dorfman, Damián Rosenstein, Ruth E. A novel viewpoint in glaucoma therapeutics: enriched environment |
title | A novel viewpoint in glaucoma therapeutics: enriched environment |
title_full | A novel viewpoint in glaucoma therapeutics: enriched environment |
title_fullStr | A novel viewpoint in glaucoma therapeutics: enriched environment |
title_full_unstemmed | A novel viewpoint in glaucoma therapeutics: enriched environment |
title_short | A novel viewpoint in glaucoma therapeutics: enriched environment |
title_sort | novel viewpoint in glaucoma therapeutics: enriched environment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771091/ https://www.ncbi.nlm.nih.gov/pubmed/34916414 http://dx.doi.org/10.4103/1673-5374.330594 |
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