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Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when compared to traditional designs such as the 3 + 3 design. However, impleme...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771176/ https://www.ncbi.nlm.nih.gov/pubmed/35057758 http://dx.doi.org/10.1186/s12874-022-01512-0 |