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Top1p targeting by Fob1p at the ribosomal Replication Fork Barrier does not account for camptothecin sensitivity in Saccharomyces cerevisiae cells

Camptothecin (CPT) is a specific inhibitor of the DNA topoisomerase I (Top1p), currently used in cancer therapy, which induces DNA damage and cell death. Top1p is highly active at the repeated ribosomal DNA locus (rDNA) to relax DNA supercoiling caused by elevated transcription and replication occur...

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Detalles Bibliográficos
Autores principales:	Pourali, Pardis, Pasero, Philippe, Pardo, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2022
Materias:	Negative Result
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771244/ https://www.ncbi.nlm.nih.gov/pubmed/35071999 http://dx.doi.org/10.17912/micropub.biology.000514

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