Exceptional response to lurbinectedin and irinotecan in BRCA-mutated platinum-resistant ovarian cancer patient: a case report

Lurbinectedin is responsible for DNA recognition and binding, producing double-strand DNA (dsDNA) breaks thus resulting in apoptosis. Sensitivity to lurbinectedin is linked to the nucleotide excision repair (NER) system. Furthermore, irinotecan, a topoisomerase I inhibitor, provokes dsDNA breaks tha...

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Detalles Bibliográficos
Autores principales: Cortesi, Laura, Venturelli, Marta, Barbieri, Elena, Baldessari, Cinzia, Bardasi, Camilla, Coccia, Emanuele, Baglio, Federica, Rimini, Margherita, Greco, Stefano, Napolitano, Martina, Pipitone, Stefania, Dominici, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771728/
https://www.ncbi.nlm.nih.gov/pubmed/35070248
http://dx.doi.org/10.1177/20406223211063023

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