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Human Organoids as a Promising Platform for Fighting COVID-19
The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms underlying this novel virus...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771829/ https://www.ncbi.nlm.nih.gov/pubmed/35173525 http://dx.doi.org/10.7150/ijbs.64993 |
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author | Chen, Dong Su, Xi Chen, Haibo Chen, Siyan Zhao, Yongsheng Wei, Wei |
author_facet | Chen, Dong Su, Xi Chen, Haibo Chen, Siyan Zhao, Yongsheng Wei, Wei |
author_sort | Chen, Dong |
collection | PubMed |
description | The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms underlying this novel virus is crucial for both fundamental research and clinical trials in order to devise effective therapies and vaccination regimens. Basic research on SARS-CoV-2 largely depends on ex vivo models that allow viral invasion and replication. Organoid models are now emerging as a valuable tool to investigate viral biology and disease progression, serving as an efficient platform to investigate potential therapies for COVID-19. Here, we summarize various human stem cell-derived organoid types employed in SARS-CoV-2 studies. We highlight key findings from these models, including cell tropisms and molecular mechanisms in viral infection. We also describe their use in identifying potential therapeutic agents against SARS-CoV-2. As more and more advanced organoids emerge, they will facilitate the understanding of disease pathogenesis for drug development in this dreaded pandemic. |
format | Online Article Text |
id | pubmed-8771829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-87718292022-02-15 Human Organoids as a Promising Platform for Fighting COVID-19 Chen, Dong Su, Xi Chen, Haibo Chen, Siyan Zhao, Yongsheng Wei, Wei Int J Biol Sci Review The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms underlying this novel virus is crucial for both fundamental research and clinical trials in order to devise effective therapies and vaccination regimens. Basic research on SARS-CoV-2 largely depends on ex vivo models that allow viral invasion and replication. Organoid models are now emerging as a valuable tool to investigate viral biology and disease progression, serving as an efficient platform to investigate potential therapies for COVID-19. Here, we summarize various human stem cell-derived organoid types employed in SARS-CoV-2 studies. We highlight key findings from these models, including cell tropisms and molecular mechanisms in viral infection. We also describe their use in identifying potential therapeutic agents against SARS-CoV-2. As more and more advanced organoids emerge, they will facilitate the understanding of disease pathogenesis for drug development in this dreaded pandemic. Ivyspring International Publisher 2022-01-01 /pmc/articles/PMC8771829/ /pubmed/35173525 http://dx.doi.org/10.7150/ijbs.64993 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Chen, Dong Su, Xi Chen, Haibo Chen, Siyan Zhao, Yongsheng Wei, Wei Human Organoids as a Promising Platform for Fighting COVID-19 |
title | Human Organoids as a Promising Platform for Fighting COVID-19 |
title_full | Human Organoids as a Promising Platform for Fighting COVID-19 |
title_fullStr | Human Organoids as a Promising Platform for Fighting COVID-19 |
title_full_unstemmed | Human Organoids as a Promising Platform for Fighting COVID-19 |
title_short | Human Organoids as a Promising Platform for Fighting COVID-19 |
title_sort | human organoids as a promising platform for fighting covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771829/ https://www.ncbi.nlm.nih.gov/pubmed/35173525 http://dx.doi.org/10.7150/ijbs.64993 |
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