Pharmacologic IRE1α kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis

Aortic dissection (AD) is a rare but catastrophic disorder, and associated with significant morbidity among survivors. This study aimed to target IRE1α-XBP1s pathway pharmacologically, and evaluate its therapeutic potential in the occurrence and progression of AD. Western Blot and immunohistochemist...

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Detalles Bibliográficos
Autores principales: Zhang, Wenjun, Wang, Mengwen, Gao, Kun, Zhong, Xiaodan, Xie, Yang, Dai, Lei, Liu, Wanjun, Liu, Yujian, He, Xingwei, Li, Shiliang, Madhusudhan, Thati, Wang, Hongjie, Zeng, Hesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771832/
https://www.ncbi.nlm.nih.gov/pubmed/35173538
http://dx.doi.org/10.7150/ijbs.63593

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