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Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target
Purpose of Review: Atherosclerosis is the principal cause of cardiovascular diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an essential role in cardiovascular health and disease. To bring the awareness of mechanosensitive Piezo1 role in atherosclerosis and its t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771847/ https://www.ncbi.nlm.nih.gov/pubmed/35173527 http://dx.doi.org/10.7150/ijbs.63819 |
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author | Shinge, Shafiu A. Umar Zhang, Daifang Din, Ahmad Ud Yu, FengXu Nie, YongMei |
author_facet | Shinge, Shafiu A. Umar Zhang, Daifang Din, Ahmad Ud Yu, FengXu Nie, YongMei |
author_sort | Shinge, Shafiu A. Umar |
collection | PubMed |
description | Purpose of Review: Atherosclerosis is the principal cause of cardiovascular diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an essential role in cardiovascular health and disease. To bring the awareness of mechanosensitive Piezo1 role in atherosclerosis and its therapeutic potentials we review recent literature to highlight its involvement in various mechanisms of the disease. Recent Findings: Recent studies reported Piezo1 channel as a sensor, and transducer of various mechanical forces into biochemical signals, which affect various cellular activities such as proliferation, migration, apoptosis and vascular remodeling including immune/inflammatory mechanisms fundamental phenomenon in atherogenesis. Summary: Numerous evidences suggest Piezo1 as a player in different mechanisms of cell biology, including immune/inflammatory and other cellular mechanisms correlated with atherosclerosis. This review discusses mechanistic insight about this matter and highlights the drugability and therapeutic potentials consistent with emerging functions Piezo1 in various mechanisms of atherosclerosis. Based on the recent works, we suggest Piezo1 as potential therapeutic target and a valid candidate for future research. Therefore, a deeper exploration of Piezo1 biology and translation towards the clinic will be a novel strategy for treating atherosclerosis and other CVDs. |
format | Online Article Text |
id | pubmed-8771847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-87718472022-02-15 Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target Shinge, Shafiu A. Umar Zhang, Daifang Din, Ahmad Ud Yu, FengXu Nie, YongMei Int J Biol Sci Review Purpose of Review: Atherosclerosis is the principal cause of cardiovascular diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an essential role in cardiovascular health and disease. To bring the awareness of mechanosensitive Piezo1 role in atherosclerosis and its therapeutic potentials we review recent literature to highlight its involvement in various mechanisms of the disease. Recent Findings: Recent studies reported Piezo1 channel as a sensor, and transducer of various mechanical forces into biochemical signals, which affect various cellular activities such as proliferation, migration, apoptosis and vascular remodeling including immune/inflammatory mechanisms fundamental phenomenon in atherogenesis. Summary: Numerous evidences suggest Piezo1 as a player in different mechanisms of cell biology, including immune/inflammatory and other cellular mechanisms correlated with atherosclerosis. This review discusses mechanistic insight about this matter and highlights the drugability and therapeutic potentials consistent with emerging functions Piezo1 in various mechanisms of atherosclerosis. Based on the recent works, we suggest Piezo1 as potential therapeutic target and a valid candidate for future research. Therefore, a deeper exploration of Piezo1 biology and translation towards the clinic will be a novel strategy for treating atherosclerosis and other CVDs. Ivyspring International Publisher 2022-01-01 /pmc/articles/PMC8771847/ /pubmed/35173527 http://dx.doi.org/10.7150/ijbs.63819 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Shinge, Shafiu A. Umar Zhang, Daifang Din, Ahmad Ud Yu, FengXu Nie, YongMei Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
title | Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
title_full | Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
title_fullStr | Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
title_full_unstemmed | Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
title_short | Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
title_sort | emerging piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771847/ https://www.ncbi.nlm.nih.gov/pubmed/35173527 http://dx.doi.org/10.7150/ijbs.63819 |
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