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Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation

Due to the large proportion of BRCA deficiency and chromosomal instability in OS patients, poly (ADP-ribose) polymerase inhibitors (PARPi) could be an effective strategy for anti-OS therapy. In two orthotopic OS mouse models, we discovered that although PARPi had inhibitory effect on the growth of t...

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Detalles Bibliográficos
Autores principales:	Li, Fangfei, Wu, Xiaoqiu, Fu, Xuekun, Liu, Jin, Song, Wangze, Xiao, Gary Guishan, Lu, Aiping, Zhang, Ge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771856/ https://www.ncbi.nlm.nih.gov/pubmed/35173550 http://dx.doi.org/10.7150/ijbs.58784

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