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Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer

Recently, immunotherapy targeting tumor-infiltrating lymphocytes (TILs) has emerged as a critical and promising treatment in several types of cancer. However, not all cancer types have been tested in immunotherapeutic trials, and different patients and cancer types may have unpredictable clinical ou...

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Autores principales: Zheng, Ming, Li, Yi-Ming, Liu, Zhen-Yu, Zhang, Xin, Zhou, Yinghui, Jiang, Jian-Li, Zhu, Ping, Yang, Xiang-Min, Tang, Juan, Chen, Zhi-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771864/
https://www.ncbi.nlm.nih.gov/pubmed/35069521
http://dx.doi.org/10.3389/fimmu.2021.731329
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author Zheng, Ming
Li, Yi-Ming
Liu, Zhen-Yu
Zhang, Xin
Zhou, Yinghui
Jiang, Jian-Li
Zhu, Ping
Yang, Xiang-Min
Tang, Juan
Chen, Zhi-Nan
author_facet Zheng, Ming
Li, Yi-Ming
Liu, Zhen-Yu
Zhang, Xin
Zhou, Yinghui
Jiang, Jian-Li
Zhu, Ping
Yang, Xiang-Min
Tang, Juan
Chen, Zhi-Nan
author_sort Zheng, Ming
collection PubMed
description Recently, immunotherapy targeting tumor-infiltrating lymphocytes (TILs) has emerged as a critical and promising treatment in several types of cancer. However, not all cancer types have been tested in immunotherapeutic trials, and different patients and cancer types may have unpredictable clinical outcomes. This situation has created a particular exigency for analyzing the prognostic significance of tumor-infiltrating T cells (TIL-T) and B cells (TIL-B) across different cancer types. To address the critical role of TILs, the abundances of TIL-T and TIL-B cells, as determined by the protein levels of LCK and CD20, were analyzed across heterogeneous human malignancies. TIL-T and TIL-B cells showed varying prognostic significances across heterogeneous cancer types. Additionally, distinct distributions of TIL-T and TIL-B cells were observed in different cancer and tumor microenvironment (TME) subtypes. Next, we analyzed the cellular context for the TME communication network involving the well-acknowledgeable chemokine receptors of TIL-T and TIL-B cells, implying the functional interactions with TME. Additionally, these chemokine receptors, expressed by TIL-T and TIL-B cells, were remarkably correlated with the levels of TIL-T or TIL-B cell infiltrations across nearly all the cancer types, indicating these chemokine receptors as universal targets for up- and down-regulating the TIL-T and TIL-B cells. Lastly, we provide the prognostic landscape of TIL-T and TIL-B cells across 30 cancer types and the subgroups defined by gender, histopathology, histological grade, therapeutic approach, drug, and TME subtype, which are intended to be a resource to fuel the investigations of TILs, with important implications for cancer immunotherapy.
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spelling pubmed-87718642022-01-21 Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer Zheng, Ming Li, Yi-Ming Liu, Zhen-Yu Zhang, Xin Zhou, Yinghui Jiang, Jian-Li Zhu, Ping Yang, Xiang-Min Tang, Juan Chen, Zhi-Nan Front Immunol Immunology Recently, immunotherapy targeting tumor-infiltrating lymphocytes (TILs) has emerged as a critical and promising treatment in several types of cancer. However, not all cancer types have been tested in immunotherapeutic trials, and different patients and cancer types may have unpredictable clinical outcomes. This situation has created a particular exigency for analyzing the prognostic significance of tumor-infiltrating T cells (TIL-T) and B cells (TIL-B) across different cancer types. To address the critical role of TILs, the abundances of TIL-T and TIL-B cells, as determined by the protein levels of LCK and CD20, were analyzed across heterogeneous human malignancies. TIL-T and TIL-B cells showed varying prognostic significances across heterogeneous cancer types. Additionally, distinct distributions of TIL-T and TIL-B cells were observed in different cancer and tumor microenvironment (TME) subtypes. Next, we analyzed the cellular context for the TME communication network involving the well-acknowledgeable chemokine receptors of TIL-T and TIL-B cells, implying the functional interactions with TME. Additionally, these chemokine receptors, expressed by TIL-T and TIL-B cells, were remarkably correlated with the levels of TIL-T or TIL-B cell infiltrations across nearly all the cancer types, indicating these chemokine receptors as universal targets for up- and down-regulating the TIL-T and TIL-B cells. Lastly, we provide the prognostic landscape of TIL-T and TIL-B cells across 30 cancer types and the subgroups defined by gender, histopathology, histological grade, therapeutic approach, drug, and TME subtype, which are intended to be a resource to fuel the investigations of TILs, with important implications for cancer immunotherapy. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8771864/ /pubmed/35069521 http://dx.doi.org/10.3389/fimmu.2021.731329 Text en Copyright © 2022 Zheng, Li, Liu, Zhang, Zhou, Jiang, Zhu, Yang, Tang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Ming
Li, Yi-Ming
Liu, Zhen-Yu
Zhang, Xin
Zhou, Yinghui
Jiang, Jian-Li
Zhu, Ping
Yang, Xiang-Min
Tang, Juan
Chen, Zhi-Nan
Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
title Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
title_full Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
title_fullStr Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
title_full_unstemmed Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
title_short Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
title_sort prognostic landscape of tumor-infiltrating t and b cells in human cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771864/
https://www.ncbi.nlm.nih.gov/pubmed/35069521
http://dx.doi.org/10.3389/fimmu.2021.731329
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