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Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
[Image: see text] Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core–shell structured plasmonic–magnetic nanocomposite system...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771950/ https://www.ncbi.nlm.nih.gov/pubmed/35071891 http://dx.doi.org/10.1021/acsomega.1c05486 |
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author | Qiu, Enhui Chen, Xiaofang Yang, Da-Peng Regulacio, Michelle D. Ramos, Rufus Mart Ceasar R. Luo, Zheng Wu, Yun-Long Lin, Ming Li, Zibiao Loh, Xian Jun Ye, Enyi |
author_facet | Qiu, Enhui Chen, Xiaofang Yang, Da-Peng Regulacio, Michelle D. Ramos, Rufus Mart Ceasar R. Luo, Zheng Wu, Yun-Long Lin, Ming Li, Zibiao Loh, Xian Jun Ye, Enyi |
author_sort | Qiu, Enhui |
collection | PubMed |
description | [Image: see text] Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core–shell structured plasmonic–magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe(2)O(4) shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids’ excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T(2)-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic–magnetic functionality, these Au@MgFe(2)O(4) nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing. |
format | Online Article Text |
id | pubmed-8771950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87719502022-01-21 Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging Qiu, Enhui Chen, Xiaofang Yang, Da-Peng Regulacio, Michelle D. Ramos, Rufus Mart Ceasar R. Luo, Zheng Wu, Yun-Long Lin, Ming Li, Zibiao Loh, Xian Jun Ye, Enyi ACS Omega [Image: see text] Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core–shell structured plasmonic–magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe(2)O(4) shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids’ excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T(2)-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic–magnetic functionality, these Au@MgFe(2)O(4) nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing. American Chemical Society 2022-01-07 /pmc/articles/PMC8771950/ /pubmed/35071891 http://dx.doi.org/10.1021/acsomega.1c05486 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Qiu, Enhui Chen, Xiaofang Yang, Da-Peng Regulacio, Michelle D. Ramos, Rufus Mart Ceasar R. Luo, Zheng Wu, Yun-Long Lin, Ming Li, Zibiao Loh, Xian Jun Ye, Enyi Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging |
title | Fabricating Dual-Functional Plasmonic–Magnetic
Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy
and Magnetic Resonance Imaging |
title_full | Fabricating Dual-Functional Plasmonic–Magnetic
Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy
and Magnetic Resonance Imaging |
title_fullStr | Fabricating Dual-Functional Plasmonic–Magnetic
Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy
and Magnetic Resonance Imaging |
title_full_unstemmed | Fabricating Dual-Functional Plasmonic–Magnetic
Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy
and Magnetic Resonance Imaging |
title_short | Fabricating Dual-Functional Plasmonic–Magnetic
Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy
and Magnetic Resonance Imaging |
title_sort | fabricating dual-functional plasmonic–magnetic
au@mgfe(2)o(4) nanohybrids for photothermal therapy
and magnetic resonance imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771950/ https://www.ncbi.nlm.nih.gov/pubmed/35071891 http://dx.doi.org/10.1021/acsomega.1c05486 |
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