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Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging

[Image: see text] Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core–shell structured plasmonic–magnetic nanocomposite system...

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Autores principales: Qiu, Enhui, Chen, Xiaofang, Yang, Da-Peng, Regulacio, Michelle D., Ramos, Rufus Mart Ceasar R., Luo, Zheng, Wu, Yun-Long, Lin, Ming, Li, Zibiao, Loh, Xian Jun, Ye, Enyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771950/
https://www.ncbi.nlm.nih.gov/pubmed/35071891
http://dx.doi.org/10.1021/acsomega.1c05486
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author Qiu, Enhui
Chen, Xiaofang
Yang, Da-Peng
Regulacio, Michelle D.
Ramos, Rufus Mart Ceasar R.
Luo, Zheng
Wu, Yun-Long
Lin, Ming
Li, Zibiao
Loh, Xian Jun
Ye, Enyi
author_facet Qiu, Enhui
Chen, Xiaofang
Yang, Da-Peng
Regulacio, Michelle D.
Ramos, Rufus Mart Ceasar R.
Luo, Zheng
Wu, Yun-Long
Lin, Ming
Li, Zibiao
Loh, Xian Jun
Ye, Enyi
author_sort Qiu, Enhui
collection PubMed
description [Image: see text] Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core–shell structured plasmonic–magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe(2)O(4) shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids’ excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T(2)-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic–magnetic functionality, these Au@MgFe(2)O(4) nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing.
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spelling pubmed-87719502022-01-21 Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging Qiu, Enhui Chen, Xiaofang Yang, Da-Peng Regulacio, Michelle D. Ramos, Rufus Mart Ceasar R. Luo, Zheng Wu, Yun-Long Lin, Ming Li, Zibiao Loh, Xian Jun Ye, Enyi ACS Omega [Image: see text] Bifunctional nanohybrids possessing both plasmonic and magnetic functionalities are of great interest for biomedical applications owing to their capability for simultaneous therapy and diagnostics. Herein, we fabricate a core–shell structured plasmonic–magnetic nanocomposite system that can serve as a dual-functional agent due to its combined photothermal therapeutic and magnetic resonance imaging (MRI) functions. The photothermal activity of the hybrid is attributed to its plasmonic Au core, which is capable of absorbing near-infrared (NIR) light and converting it into heat. Meanwhile, the magnetic MgFe(2)O(4) shell exerts its ability to act as a MRI contrast agent. Our in vivo studies using tumor-bearing mice demonstrated the nanohybrids’ excellent photothermal and MRI properties. As a photothermal therapeutic agent, the nanohybrids were able to dramatically shrink solid tumors in mice through NIR-induced hyperthermia. As T(2)-weighted MRI contrast agents, the nanohybrids were found capable of substantially reducing the MRI signal intensity of the tumor region at 10 min postinjection. With their dual plasmonic–magnetic functionality, these Au@MgFe(2)O(4) nanohybrids hold great promise not only in the biomedical field but also in the areas of catalysis and optical sensing. American Chemical Society 2022-01-07 /pmc/articles/PMC8771950/ /pubmed/35071891 http://dx.doi.org/10.1021/acsomega.1c05486 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Qiu, Enhui
Chen, Xiaofang
Yang, Da-Peng
Regulacio, Michelle D.
Ramos, Rufus Mart Ceasar R.
Luo, Zheng
Wu, Yun-Long
Lin, Ming
Li, Zibiao
Loh, Xian Jun
Ye, Enyi
Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
title Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
title_full Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
title_fullStr Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
title_full_unstemmed Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
title_short Fabricating Dual-Functional Plasmonic–Magnetic Au@MgFe(2)O(4) Nanohybrids for Photothermal Therapy and Magnetic Resonance Imaging
title_sort fabricating dual-functional plasmonic–magnetic au@mgfe(2)o(4) nanohybrids for photothermal therapy and magnetic resonance imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771950/
https://www.ncbi.nlm.nih.gov/pubmed/35071891
http://dx.doi.org/10.1021/acsomega.1c05486
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