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The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex

BACKGROUND: The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemp...

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Autores principales: Singleton, E. H., Pijnenburg, Y. A. L., Gami-Patel, P., Boon, B. D. C., Bouwman, F., Papma, J. M., Seelaar, H., Scheltens, P., Grinberg, L. T., Spina, S., Nana, A. L., Rabinovici, G. D., Seeley, W. W., Ossenkoppele, R., Dijkstra, A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772094/
https://www.ncbi.nlm.nih.gov/pubmed/35057846
http://dx.doi.org/10.1186/s13195-021-00947-9
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author Singleton, E. H.
Pijnenburg, Y. A. L.
Gami-Patel, P.
Boon, B. D. C.
Bouwman, F.
Papma, J. M.
Seelaar, H.
Scheltens, P.
Grinberg, L. T.
Spina, S.
Nana, A. L.
Rabinovici, G. D.
Seeley, W. W.
Ossenkoppele, R.
Dijkstra, A. A.
author_facet Singleton, E. H.
Pijnenburg, Y. A. L.
Gami-Patel, P.
Boon, B. D. C.
Bouwman, F.
Papma, J. M.
Seelaar, H.
Scheltens, P.
Grinberg, L. T.
Spina, S.
Nana, A. L.
Rabinovici, G. D.
Seeley, W. W.
Ossenkoppele, R.
Dijkstra, A. A.
author_sort Singleton, E. H.
collection PubMed
description BACKGROUND: The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neuronal populations show a selective loss in bvAD. METHODS: VENs and GABA receptor subunit theta (GABRQ)-immunoreactive pyramidal neurons of the anterior cingulate cortex (ACC) were quantified in post-mortem tissue of patients with bvAD (n = 9) and compared to typical AD (tAD, n = 6), bvFTD due to frontotemporal lobar degeneration based on TDP-43 pathology (FTLD, n = 18) and controls (n = 13) using ANCOVAs adjusted for age and Bonferroni corrected. In addition, ratios of VENs and GABRQ-immunoreactive (GABRQ-ir) pyramidal neurons over all Layer 5 neurons were compared between groups to correct for overall Layer 5 neuronal loss. RESULTS: The number of VENs or GABRQ-ir neurons did not differ significantly between bvAD (VENs: 26.0 ± 15.3, GABRQ-ir pyramidal: 260.4 ± 87.1) and tAD (VENs: 32.0 ± 18.1, p = 1.00, GABRQ-ir pyramidal: 349.8 ± 109.6, p = 0.38) and controls (VENs: 33.5 ± 20.3, p = 1.00, GABRQ-ir pyramidal: 339.4 ± 95.9, p = 0.37). Compared to bvFTD, patients with bvAD showed significantly more GABRQ-ir pyramidal neurons (bvFTD: 140.5 ± 82.658, p = 0.01) and no significant differences in number of VENs (bvFTD: 10.9 ± 13.8, p = 0.13). Results were similar when assessing the number of VENs and GABRQ-ir relative to all neurons of Layer 5. DISCUSSION: VENs and phylogenetically related neurons did not show a selective loss in the ACC in patients with bvAD. Our results suggest that, unlike in bvFTD, the clinical presentation in bvAD may not be related to the loss of VENs and related neurons in the ACC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-021-00947-9.
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spelling pubmed-87720942022-01-20 The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex Singleton, E. H. Pijnenburg, Y. A. L. Gami-Patel, P. Boon, B. D. C. Bouwman, F. Papma, J. M. Seelaar, H. Scheltens, P. Grinberg, L. T. Spina, S. Nana, A. L. Rabinovici, G. D. Seeley, W. W. Ossenkoppele, R. Dijkstra, A. A. Alzheimers Res Ther Research BACKGROUND: The neurobiological origins of the early and predominant behavioral changes seen in the behavioral variant of Alzheimer’s disease (bvAD) remain unclear. A selective loss of Von Economo neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases. Here, we assessed whether these specific neuronal populations show a selective loss in bvAD. METHODS: VENs and GABA receptor subunit theta (GABRQ)-immunoreactive pyramidal neurons of the anterior cingulate cortex (ACC) were quantified in post-mortem tissue of patients with bvAD (n = 9) and compared to typical AD (tAD, n = 6), bvFTD due to frontotemporal lobar degeneration based on TDP-43 pathology (FTLD, n = 18) and controls (n = 13) using ANCOVAs adjusted for age and Bonferroni corrected. In addition, ratios of VENs and GABRQ-immunoreactive (GABRQ-ir) pyramidal neurons over all Layer 5 neurons were compared between groups to correct for overall Layer 5 neuronal loss. RESULTS: The number of VENs or GABRQ-ir neurons did not differ significantly between bvAD (VENs: 26.0 ± 15.3, GABRQ-ir pyramidal: 260.4 ± 87.1) and tAD (VENs: 32.0 ± 18.1, p = 1.00, GABRQ-ir pyramidal: 349.8 ± 109.6, p = 0.38) and controls (VENs: 33.5 ± 20.3, p = 1.00, GABRQ-ir pyramidal: 339.4 ± 95.9, p = 0.37). Compared to bvFTD, patients with bvAD showed significantly more GABRQ-ir pyramidal neurons (bvFTD: 140.5 ± 82.658, p = 0.01) and no significant differences in number of VENs (bvFTD: 10.9 ± 13.8, p = 0.13). Results were similar when assessing the number of VENs and GABRQ-ir relative to all neurons of Layer 5. DISCUSSION: VENs and phylogenetically related neurons did not show a selective loss in the ACC in patients with bvAD. Our results suggest that, unlike in bvFTD, the clinical presentation in bvAD may not be related to the loss of VENs and related neurons in the ACC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-021-00947-9. BioMed Central 2022-01-20 /pmc/articles/PMC8772094/ /pubmed/35057846 http://dx.doi.org/10.1186/s13195-021-00947-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Singleton, E. H.
Pijnenburg, Y. A. L.
Gami-Patel, P.
Boon, B. D. C.
Bouwman, F.
Papma, J. M.
Seelaar, H.
Scheltens, P.
Grinberg, L. T.
Spina, S.
Nana, A. L.
Rabinovici, G. D.
Seeley, W. W.
Ossenkoppele, R.
Dijkstra, A. A.
The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
title The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
title_full The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
title_fullStr The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
title_full_unstemmed The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
title_short The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
title_sort behavioral variant of alzheimer’s disease does not show a selective loss of von economo and phylogenetically related neurons in the anterior cingulate cortex
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772094/
https://www.ncbi.nlm.nih.gov/pubmed/35057846
http://dx.doi.org/10.1186/s13195-021-00947-9
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