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Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa

BACKGROUND: Antenatal depression is associated with intrauterine growth retardation, preterm birth, and low birth weight. Infants born to mothers with postnatal depression also may suffer from malnutrition and other health problems. Even though there are few single studies conducted so far, a system...

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Autores principales: Dadi, Abel Fekadu, Akalu, Temesgen Yihunie, Wolde, Haileab Fekadu, Baraki, Adhanom Gebreegziabher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772173/
https://www.ncbi.nlm.nih.gov/pubmed/35057865
http://dx.doi.org/10.1186/s13690-022-00792-8
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author Dadi, Abel Fekadu
Akalu, Temesgen Yihunie
Wolde, Haileab Fekadu
Baraki, Adhanom Gebreegziabher
author_facet Dadi, Abel Fekadu
Akalu, Temesgen Yihunie
Wolde, Haileab Fekadu
Baraki, Adhanom Gebreegziabher
author_sort Dadi, Abel Fekadu
collection PubMed
description BACKGROUND: Antenatal depression is associated with intrauterine growth retardation, preterm birth, and low birth weight. Infants born to mothers with postnatal depression also may suffer from malnutrition and other health problems. Even though there are few single studies conducted so far, a systematic review of these studies is highly important to highlight the effect of antenatal and perinatal depression on adverse birth and infant health outcomes in Africa. METHODS: We used the Preferred Report Items for Systematic Review and Meta-analysis (PRISMA) when conducting this study. Databases like CINAHL (EBSCO), MEDLINE (via Ovid and PubMed), PsycINFO, Emcare, Psychiatry Online, and Scopus were searched. In addition, Google Scholar and references from a list of eligible studies were explored. We included good quality observational studies based on Newcastle Ottawa Scale which are published in the English language between 2007 and 2018.  Heterogeneity and publication bias were assessed. Meta-analysis with a random effect model was employed to determine the pooled effect sizes with a 95% confidence interval. The review protocol is registered in PROSPERO (CRD42018106714). RESULT: We found three studies (1511 participants) and 11 studies (22,254 participants) conducted on the effect of antenatal depression on birth outcomes and perinatal depression on adverse infant health outcomes, respectively. The overall risk of having adverse birth outcomes was 2.26 (95% CI: 1.43, 3.58) times higher among pregnant mothers with depression. The risk of preterm birth and low birth weight was 1.77 (95% CI: 1.03, 3.04) and 2.98 (95% CI: 1.60, 5.55) respectively. Similarly, the risk of having adverse infant health outcomes namely malnutrition and febrile illness was 1.61 (95% CI: 1.34, 1.95) times higher among mothers who had perinatal depression. CONCLUSIONS: We have found a significant association between antenatal depression and adverse birth outcomes, low birth weight and preterm birth. Similarly, a significant effect of perinatal depression on adverse infant health outcomes namely, malnutrition, and febrile illnesses was observed. The findings highlight that it is time to integrate mental health services with routine maternal health care services to improve birth outcomes and reduce infant morbidity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13690-022-00792-8.
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spelling pubmed-87721732022-01-20 Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa Dadi, Abel Fekadu Akalu, Temesgen Yihunie Wolde, Haileab Fekadu Baraki, Adhanom Gebreegziabher Arch Public Health Systematic Review BACKGROUND: Antenatal depression is associated with intrauterine growth retardation, preterm birth, and low birth weight. Infants born to mothers with postnatal depression also may suffer from malnutrition and other health problems. Even though there are few single studies conducted so far, a systematic review of these studies is highly important to highlight the effect of antenatal and perinatal depression on adverse birth and infant health outcomes in Africa. METHODS: We used the Preferred Report Items for Systematic Review and Meta-analysis (PRISMA) when conducting this study. Databases like CINAHL (EBSCO), MEDLINE (via Ovid and PubMed), PsycINFO, Emcare, Psychiatry Online, and Scopus were searched. In addition, Google Scholar and references from a list of eligible studies were explored. We included good quality observational studies based on Newcastle Ottawa Scale which are published in the English language between 2007 and 2018.  Heterogeneity and publication bias were assessed. Meta-analysis with a random effect model was employed to determine the pooled effect sizes with a 95% confidence interval. The review protocol is registered in PROSPERO (CRD42018106714). RESULT: We found three studies (1511 participants) and 11 studies (22,254 participants) conducted on the effect of antenatal depression on birth outcomes and perinatal depression on adverse infant health outcomes, respectively. The overall risk of having adverse birth outcomes was 2.26 (95% CI: 1.43, 3.58) times higher among pregnant mothers with depression. The risk of preterm birth and low birth weight was 1.77 (95% CI: 1.03, 3.04) and 2.98 (95% CI: 1.60, 5.55) respectively. Similarly, the risk of having adverse infant health outcomes namely malnutrition and febrile illness was 1.61 (95% CI: 1.34, 1.95) times higher among mothers who had perinatal depression. CONCLUSIONS: We have found a significant association between antenatal depression and adverse birth outcomes, low birth weight and preterm birth. Similarly, a significant effect of perinatal depression on adverse infant health outcomes namely, malnutrition, and febrile illnesses was observed. The findings highlight that it is time to integrate mental health services with routine maternal health care services to improve birth outcomes and reduce infant morbidity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13690-022-00792-8. BioMed Central 2022-01-20 /pmc/articles/PMC8772173/ /pubmed/35057865 http://dx.doi.org/10.1186/s13690-022-00792-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Systematic Review
Dadi, Abel Fekadu
Akalu, Temesgen Yihunie
Wolde, Haileab Fekadu
Baraki, Adhanom Gebreegziabher
Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
title Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
title_full Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
title_fullStr Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
title_full_unstemmed Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
title_short Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
title_sort effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from africa
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772173/
https://www.ncbi.nlm.nih.gov/pubmed/35057865
http://dx.doi.org/10.1186/s13690-022-00792-8
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