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Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of diagnosis. Several palliative interventions for ESCC are currently in use with...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772224/ https://www.ncbi.nlm.nih.gov/pubmed/35045815 http://dx.doi.org/10.1186/s12885-021-09124-5 |
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author | Buckle, Geoffrey C. Mrema, Alita Mwachiro, Michael Ringo, Yona Selekwa, Msiba Mulima, Gift Some, Fatma F. Mmbaga, Blandina T. Mody, Gita N. Zhang, Li Paciorek, Alan Akoko, Larry Ayuo, Paul Burgert, Stephen Bukusi, Elizabeth Charles, Anthony Chepkemoi, Winnie Chesumbai, Gladys Kaimila, Bongani Kenseko, Aida Kibwana, Kitembo Salum Koech, David Macharia, Caren Moirana, Ezekiel N. Mushi, Beatrice Paul Mremi, Alex Mwaiselage, Julius Mwanga, Ally Ndumbalo, Jerry Nvakunga, Gissela Ngoma, Mamsau Oduor, Margaret Oloo, Mark Opakas, Jesse Parker, Robert Seno, Saruni Salima, Ande Servent, Furaha Wandera, Andrew Westmoreland, Kate D. White, Russell E. Williams, Brittney Mmbaga, Elia J. Van Loon, Katherine |
author_facet | Buckle, Geoffrey C. Mrema, Alita Mwachiro, Michael Ringo, Yona Selekwa, Msiba Mulima, Gift Some, Fatma F. Mmbaga, Blandina T. Mody, Gita N. Zhang, Li Paciorek, Alan Akoko, Larry Ayuo, Paul Burgert, Stephen Bukusi, Elizabeth Charles, Anthony Chepkemoi, Winnie Chesumbai, Gladys Kaimila, Bongani Kenseko, Aida Kibwana, Kitembo Salum Koech, David Macharia, Caren Moirana, Ezekiel N. Mushi, Beatrice Paul Mremi, Alex Mwaiselage, Julius Mwanga, Ally Ndumbalo, Jerry Nvakunga, Gissela Ngoma, Mamsau Oduor, Margaret Oloo, Mark Opakas, Jesse Parker, Robert Seno, Saruni Salima, Ande Servent, Furaha Wandera, Andrew Westmoreland, Kate D. White, Russell E. Williams, Brittney Mmbaga, Elia J. Van Loon, Katherine |
author_sort | Buckle, Geoffrey C. |
collection | PubMed |
description | BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of diagnosis. Several palliative interventions for ESCC are currently in use within the region, including chemotherapy, radiation therapy with and without chemotherapy, and esophageal stenting with self-expandable metallic stents; however, the comparative effectiveness of these interventions in a low resource setting has yet to be examined. METHODS: This prospective, observational, multi-center, open cohort study aims to describe the therapeutic landscape of ESCC in Eastern Africa and investigate the outcomes of different treatment strategies within the region. The 4.5-year study will recruit at a total of six sites in Kenya, Malawi and Tanzania (Ocean Road Cancer Institute and Muhimbili National Hospital in Dar es Salaam, Tanzania; Kilimanjaro Christian Medical Center in Moshi, Tanzania; Tenwek Hospital in Bomet, Kenya; Moi Teaching and Referral Hospital in Eldoret, Kenya; and Kamuzu Central Hospital in Lilongwe, Malawi). Treatment outcomes that will be evaluated include overall survival, quality of life (QOL) and safety. All patients (≥18 years old) who present to participating sites with a histopathologically-confirmed or presumptive clinical diagnosis of ESCC based on endoscopy or barium swallow will be recruited to participate. Key clinical and treatment-related data including standardized QOL metrics will be collected at study enrollment, 1 month following treatment, 3 months following treatment, and thereafter at 3-month intervals until death. Vital status and QOL data will be collected through mobile phone outreach. DISCUSSION: This study will be the first study to prospectively compare ESCC treatment strategies in Eastern Africa, and the first to investigate QOL benefits associated with different treatments in sub-Saharan Africa. Findings from this study will help define optimal management strategies for ESCC in Eastern Africa and other resource-limited settings and will serve as a benchmark for future research. TRIAL REGISTRATION: This study was retrospectively registered with the ClinicalTrials.gov database on December 15, 2021, NCT05177393. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-09124-5. |
format | Online Article Text |
id | pubmed-8772224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87722242022-01-20 Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study Buckle, Geoffrey C. Mrema, Alita Mwachiro, Michael Ringo, Yona Selekwa, Msiba Mulima, Gift Some, Fatma F. Mmbaga, Blandina T. Mody, Gita N. Zhang, Li Paciorek, Alan Akoko, Larry Ayuo, Paul Burgert, Stephen Bukusi, Elizabeth Charles, Anthony Chepkemoi, Winnie Chesumbai, Gladys Kaimila, Bongani Kenseko, Aida Kibwana, Kitembo Salum Koech, David Macharia, Caren Moirana, Ezekiel N. Mushi, Beatrice Paul Mremi, Alex Mwaiselage, Julius Mwanga, Ally Ndumbalo, Jerry Nvakunga, Gissela Ngoma, Mamsau Oduor, Margaret Oloo, Mark Opakas, Jesse Parker, Robert Seno, Saruni Salima, Ande Servent, Furaha Wandera, Andrew Westmoreland, Kate D. White, Russell E. Williams, Brittney Mmbaga, Elia J. Van Loon, Katherine BMC Cancer Study Protocol BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of diagnosis. Several palliative interventions for ESCC are currently in use within the region, including chemotherapy, radiation therapy with and without chemotherapy, and esophageal stenting with self-expandable metallic stents; however, the comparative effectiveness of these interventions in a low resource setting has yet to be examined. METHODS: This prospective, observational, multi-center, open cohort study aims to describe the therapeutic landscape of ESCC in Eastern Africa and investigate the outcomes of different treatment strategies within the region. The 4.5-year study will recruit at a total of six sites in Kenya, Malawi and Tanzania (Ocean Road Cancer Institute and Muhimbili National Hospital in Dar es Salaam, Tanzania; Kilimanjaro Christian Medical Center in Moshi, Tanzania; Tenwek Hospital in Bomet, Kenya; Moi Teaching and Referral Hospital in Eldoret, Kenya; and Kamuzu Central Hospital in Lilongwe, Malawi). Treatment outcomes that will be evaluated include overall survival, quality of life (QOL) and safety. All patients (≥18 years old) who present to participating sites with a histopathologically-confirmed or presumptive clinical diagnosis of ESCC based on endoscopy or barium swallow will be recruited to participate. Key clinical and treatment-related data including standardized QOL metrics will be collected at study enrollment, 1 month following treatment, 3 months following treatment, and thereafter at 3-month intervals until death. Vital status and QOL data will be collected through mobile phone outreach. DISCUSSION: This study will be the first study to prospectively compare ESCC treatment strategies in Eastern Africa, and the first to investigate QOL benefits associated with different treatments in sub-Saharan Africa. Findings from this study will help define optimal management strategies for ESCC in Eastern Africa and other resource-limited settings and will serve as a benchmark for future research. TRIAL REGISTRATION: This study was retrospectively registered with the ClinicalTrials.gov database on December 15, 2021, NCT05177393. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-09124-5. BioMed Central 2022-01-19 /pmc/articles/PMC8772224/ /pubmed/35045815 http://dx.doi.org/10.1186/s12885-021-09124-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Buckle, Geoffrey C. Mrema, Alita Mwachiro, Michael Ringo, Yona Selekwa, Msiba Mulima, Gift Some, Fatma F. Mmbaga, Blandina T. Mody, Gita N. Zhang, Li Paciorek, Alan Akoko, Larry Ayuo, Paul Burgert, Stephen Bukusi, Elizabeth Charles, Anthony Chepkemoi, Winnie Chesumbai, Gladys Kaimila, Bongani Kenseko, Aida Kibwana, Kitembo Salum Koech, David Macharia, Caren Moirana, Ezekiel N. Mushi, Beatrice Paul Mremi, Alex Mwaiselage, Julius Mwanga, Ally Ndumbalo, Jerry Nvakunga, Gissela Ngoma, Mamsau Oduor, Margaret Oloo, Mark Opakas, Jesse Parker, Robert Seno, Saruni Salima, Ande Servent, Furaha Wandera, Andrew Westmoreland, Kate D. White, Russell E. Williams, Brittney Mmbaga, Elia J. Van Loon, Katherine Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study |
title | Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study |
title_full | Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study |
title_fullStr | Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study |
title_full_unstemmed | Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study |
title_short | Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study |
title_sort | treatment outcomes of esophageal cancer in eastern africa: protocol of a multi-center, prospective, observational, open cohort study |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772224/ https://www.ncbi.nlm.nih.gov/pubmed/35045815 http://dx.doi.org/10.1186/s12885-021-09124-5 |
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