Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials

The DNA vaccine, AV-1959D, targeting N-terminal epitope of Aβ peptide, has been proven immunogenic in mice, rabbits, and non-human primates, while its therapeutic efficacy has been shown in mouse models of Alzheimer's disease (AD). Here we report for the first time on IND-enabling biodistributi...

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Detalles Bibliográficos
Autores principales: Petrushina, Irina, Hovakimyan, Armine, Harahap-Carrillo, Indira S., Davtyan, Hayk, Antonyan, Tatevik, Chailyan, Gor, Kazarian, Konstantin, Antonenko, Maxim, Jullienne, Amandine, Hamer, Mary M., Obenaus, Andre, King, Olga, Zagorski, Karen, Blurton-Jones, Mathew, Cribbs, David H., Lander, Harry, Ghochikyan, Anahit, Agadjanyan, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772258/
https://www.ncbi.nlm.nih.gov/pubmed/32119976
http://dx.doi.org/10.1016/j.nbd.2020.104823

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