TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures

Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations in TET proteins are frequent in human Diffuse Large B-Cell Lymphoma (DLBCL). Here we investigate the role of TET proteins in B-...

Descripción completa

Detalles Bibliográficos
Autores principales: Shukla, Vipul, Samaniego-Castruita, Daniela, Dong, Zhen, González-Avalos, Edahí, Yan, Qingqing, Sarma, Kavitha, Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772520/
https://www.ncbi.nlm.nih.gov/pubmed/34937926
http://dx.doi.org/10.1038/s41590-021-01087-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772520/
https://www.ncbi.nlm.nih.gov/pubmed/34937926
http://dx.doi.org/10.1038/s41590-021-01087-w

Ejemplares similares