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Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU

Sepsis is a life-threatening medical emergency induced by the body′s extreme response to an infection. Despite well-defined and constantly updated criteria for diagnosing sepsis, it is still underdiagnosed worldwide. Among various markers studied over time, the neutrophil to lymphocyte ratio (NLR) r...

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Autores principales: Drăgoescu, Alice Nicoleta, Pădureanu, Vlad, Stănculescu, Andreea Doriana, Chiuțu, Luminița Cristina, Tomescu, Paul, Geormăneanu, Cristiana, Pădureanu, Rodica, Iovănescu, Vlad Florin, Ungureanu, Bogdan Silviu, Pănuș, Andrei, Drăgoescu, Octavian Petru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772781/
https://www.ncbi.nlm.nih.gov/pubmed/35052755
http://dx.doi.org/10.3390/biomedicines10010075
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author Drăgoescu, Alice Nicoleta
Pădureanu, Vlad
Stănculescu, Andreea Doriana
Chiuțu, Luminița Cristina
Tomescu, Paul
Geormăneanu, Cristiana
Pădureanu, Rodica
Iovănescu, Vlad Florin
Ungureanu, Bogdan Silviu
Pănuș, Andrei
Drăgoescu, Octavian Petru
author_facet Drăgoescu, Alice Nicoleta
Pădureanu, Vlad
Stănculescu, Andreea Doriana
Chiuțu, Luminița Cristina
Tomescu, Paul
Geormăneanu, Cristiana
Pădureanu, Rodica
Iovănescu, Vlad Florin
Ungureanu, Bogdan Silviu
Pănuș, Andrei
Drăgoescu, Octavian Petru
author_sort Drăgoescu, Alice Nicoleta
collection PubMed
description Sepsis is a life-threatening medical emergency induced by the body′s extreme response to an infection. Despite well-defined and constantly updated criteria for diagnosing sepsis, it is still underdiagnosed worldwide. Among various markers studied over time, the neutrophil to lymphocyte ratio (NLR) recently emerged as a good marker to predict sepsis severity. Our study was a single-center prospective observational study performed in our ICU and included 114 patients admitted for sepsis or septic shock. Neutrophil to lymphocyte ratio (NLR) is easy to perform, CBC being one of the standard blood tests routinely performed upon admission for all ICU patients. We found that NLR was increased in all patients with sepsis and significantly raised in those with septic shock. NLR correlates significantly with sepsis severity evaluated by the SOFA score (R = 0.65) and also with extensively studied sepsis prognosis marker presepsin (R = 0.56). Additionally, NLR showed good sensitivity (47%) and specificity (78%) with AUC = 0.631 (p < 0.05). NLR is less expensive and easier to perform compared with other specific markers and may potentially become a good alternate option for evaluation of sepsis severity. Larger studies are needed in the future to demonstrate the prognosis value of NLR.
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spelling pubmed-87727812022-01-21 Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU Drăgoescu, Alice Nicoleta Pădureanu, Vlad Stănculescu, Andreea Doriana Chiuțu, Luminița Cristina Tomescu, Paul Geormăneanu, Cristiana Pădureanu, Rodica Iovănescu, Vlad Florin Ungureanu, Bogdan Silviu Pănuș, Andrei Drăgoescu, Octavian Petru Biomedicines Article Sepsis is a life-threatening medical emergency induced by the body′s extreme response to an infection. Despite well-defined and constantly updated criteria for diagnosing sepsis, it is still underdiagnosed worldwide. Among various markers studied over time, the neutrophil to lymphocyte ratio (NLR) recently emerged as a good marker to predict sepsis severity. Our study was a single-center prospective observational study performed in our ICU and included 114 patients admitted for sepsis or septic shock. Neutrophil to lymphocyte ratio (NLR) is easy to perform, CBC being one of the standard blood tests routinely performed upon admission for all ICU patients. We found that NLR was increased in all patients with sepsis and significantly raised in those with septic shock. NLR correlates significantly with sepsis severity evaluated by the SOFA score (R = 0.65) and also with extensively studied sepsis prognosis marker presepsin (R = 0.56). Additionally, NLR showed good sensitivity (47%) and specificity (78%) with AUC = 0.631 (p < 0.05). NLR is less expensive and easier to perform compared with other specific markers and may potentially become a good alternate option for evaluation of sepsis severity. Larger studies are needed in the future to demonstrate the prognosis value of NLR. MDPI 2021-12-30 /pmc/articles/PMC8772781/ /pubmed/35052755 http://dx.doi.org/10.3390/biomedicines10010075 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Drăgoescu, Alice Nicoleta
Pădureanu, Vlad
Stănculescu, Andreea Doriana
Chiuțu, Luminița Cristina
Tomescu, Paul
Geormăneanu, Cristiana
Pădureanu, Rodica
Iovănescu, Vlad Florin
Ungureanu, Bogdan Silviu
Pănuș, Andrei
Drăgoescu, Octavian Petru
Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU
title Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU
title_full Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU
title_fullStr Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU
title_full_unstemmed Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU
title_short Neutrophil to Lymphocyte Ratio (NLR)—A Useful Tool for the Prognosis of Sepsis in the ICU
title_sort neutrophil to lymphocyte ratio (nlr)—a useful tool for the prognosis of sepsis in the icu
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772781/
https://www.ncbi.nlm.nih.gov/pubmed/35052755
http://dx.doi.org/10.3390/biomedicines10010075
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