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Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study

Background: Little is known about the impacts at an individual level of long-term antibiotic consumption. We explored health outcomes of long-term antibiotic therapy prescribed to a cohort of patients to suppress infections deemed incurable. Methods: We conducted a 5-year longitudinal study of patie...

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Autores principales: Kiss, Christopher, Connoley, Declan, Connelly, Kathryn, Horne, Kylie, Korman, Tony, Woolley, Ian, Lau, Jillian S. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772790/
https://www.ncbi.nlm.nih.gov/pubmed/35052939
http://dx.doi.org/10.3390/antibiotics11010062
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author Kiss, Christopher
Connoley, Declan
Connelly, Kathryn
Horne, Kylie
Korman, Tony
Woolley, Ian
Lau, Jillian S. Y.
author_facet Kiss, Christopher
Connoley, Declan
Connelly, Kathryn
Horne, Kylie
Korman, Tony
Woolley, Ian
Lau, Jillian S. Y.
author_sort Kiss, Christopher
collection PubMed
description Background: Little is known about the impacts at an individual level of long-term antibiotic consumption. We explored health outcomes of long-term antibiotic therapy prescribed to a cohort of patients to suppress infections deemed incurable. Methods: We conducted a 5-year longitudinal study of patients on long-term antibiotics at Monash Health, a metropolitan tertiary-level hospital network in Australia. Adults prescribed antibiotics for >12 months to suppress chronic infection or prevent recurrent infection were included. A retrospective review of medical records and a descriptive analysis was conducted. Results: Twenty-seven patients were followed up during the study period, from 29 patients originally identified in Monash Health in 2014. Seven of the 27 patients (26%) died from causes unrelated to the suppressed infection, six (22%) ceased long-term antibiotic therapy and two (7%) required treatment modification. Fifteen (56%) were colonised with multiresistant microorganisms, including vancomycin resistant Enterococci, methicillin resistant Staphylococcus aureus, and carbapenem resistant Enterobacteriaciae. Conclusions: This work highlights the potential pitfalls of long-term antibiotic therapy, and the frailty of this cohort, who are often ineligible for definitive curative therapy.
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spelling pubmed-87727902022-01-21 Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study Kiss, Christopher Connoley, Declan Connelly, Kathryn Horne, Kylie Korman, Tony Woolley, Ian Lau, Jillian S. Y. Antibiotics (Basel) Brief Report Background: Little is known about the impacts at an individual level of long-term antibiotic consumption. We explored health outcomes of long-term antibiotic therapy prescribed to a cohort of patients to suppress infections deemed incurable. Methods: We conducted a 5-year longitudinal study of patients on long-term antibiotics at Monash Health, a metropolitan tertiary-level hospital network in Australia. Adults prescribed antibiotics for >12 months to suppress chronic infection or prevent recurrent infection were included. A retrospective review of medical records and a descriptive analysis was conducted. Results: Twenty-seven patients were followed up during the study period, from 29 patients originally identified in Monash Health in 2014. Seven of the 27 patients (26%) died from causes unrelated to the suppressed infection, six (22%) ceased long-term antibiotic therapy and two (7%) required treatment modification. Fifteen (56%) were colonised with multiresistant microorganisms, including vancomycin resistant Enterococci, methicillin resistant Staphylococcus aureus, and carbapenem resistant Enterobacteriaciae. Conclusions: This work highlights the potential pitfalls of long-term antibiotic therapy, and the frailty of this cohort, who are often ineligible for definitive curative therapy. MDPI 2022-01-05 /pmc/articles/PMC8772790/ /pubmed/35052939 http://dx.doi.org/10.3390/antibiotics11010062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Kiss, Christopher
Connoley, Declan
Connelly, Kathryn
Horne, Kylie
Korman, Tony
Woolley, Ian
Lau, Jillian S. Y.
Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study
title Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study
title_full Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study
title_fullStr Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study
title_full_unstemmed Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study
title_short Long-Term Outcomes in Patients on Life-Long Antibiotics: A Five-Year Cohort Study
title_sort long-term outcomes in patients on life-long antibiotics: a five-year cohort study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772790/
https://www.ncbi.nlm.nih.gov/pubmed/35052939
http://dx.doi.org/10.3390/antibiotics11010062
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