Trait-Based Vaccination of Individual Meerkats (Suricata suricatta) against Tuberculosis Provides Evidence to Support Targeted Disease Control

SIMPLE SUMMARY: There is evidence to show that, within a population, some individuals are more likely to spread infections than others. When trying to protect a population against infection, most strategies aim to vaccinate as many individuals as possible. However, vaccinating wildlife is difficult because individuals are difficult to find and capture. For wildlife therefore, the ideal strategy would involve targeting vaccinations at those individuals most likely to transmit infection, thus gaining maximum benefit from capturing a small number of individuals. Whilst this seems a very attractive solution, very few studies have attempted to provide evidence to support this theory. This study focuses on a population of meerkats with a history of tuberculosis. Previous work has suggested that socially dominant individuals are most likely to transmit infection, with subordinates most likely to become infected. Therefore, whilst some social groups were left untreated as a baseline, in others, either dominants or subordinates were vaccinated. All groups were monitored for two years, after which time the infection data was analysed. Groups in which vaccinations had been used showed reduced infection rates suggesting that the targeted approach had reduced transmission. A targeted approach may therefore offer an efficient option for vaccinating wildlife in the future. ABSTRACT: Individuals vary in their potential to acquire and transmit infections, but this fact is currently underexploited in disease control strategies. We trialled a trait-based vaccination strategy to reduce tuberculosis in free-living meerkats by targeting high-contact meerkats (socially dominant individuals) in one study arm, and high-susceptibility individuals (young subordinates) in a second arm. We monitored infection within vaccinated groups over two years comparing the results with untreated control groups. Being a member of a high-contact group had a protective effect on individuals’ survival times (Hazard Ratio = 0.5, 95% Confidence Interval, CI: 0.29–0.88, p = 0.02) compared to control groups. Over the study, odds of testing positive for tuberculosis increased more than five-fold in control groups (Odds Ratio = 5.40, 95% CI = 0.94–30.98, p = 0.058); however, no increases were observed in either of the treatment arms. Targeted disease control approaches, such as the one described in this study, allow for reduced numbers of interventions. Here, trait-based vaccination was associated with reduced infection rates and thus has the potential to offer more efficient alternatives to traditional mass-vaccination policies. Such improvements in efficiency warrant further study and could make infectious disease control more practically achievable in both animal (particularly wildlife) and human populations.