Lyz2-Cre-Mediated Genetic Deletion of Septin7 Reveals a Role of Septins in Macrophage Cytokinesis and Kras-Driven Tumorigenesis

By crossing septin7-floxed mice with Lyz2-Cre mice carrying the Cre recombinase inserted in the Lysozyme-M (Lyz2) gene locus we aimed the specific deletion of septin7 in myeloid cells, such as monocytes, macrophages and granulocytes. Septin7 ( flox/flox ):Lyz2-Cre mice show no alterations in the mye...

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Detalles Bibliográficos
Autores principales: Menon, Manoj B., Yakovleva, Tatiana, Ronkina, Natalia, Suwandi, Abdulhadi, Odak, Ivan, Dhamija, Sonam, Sandrock, Inga, Hansmann, Florian, Baumgärtner, Wolfgang, Förster, Reinhold, Kotlyarov, Alexey, Gaestel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772882/
https://www.ncbi.nlm.nih.gov/pubmed/35071236
http://dx.doi.org/10.3389/fcell.2021.795798

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