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Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D(2) Receptor
SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine D(2) receptor (D(2)R), however, the binding mode and allosteric mechanism of action of this ligand remain incompletely understood. SB269,652 comprises an orthosteric, primary pharmacophore and a secondary (...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772941/ https://www.ncbi.nlm.nih.gov/pubmed/35052702 http://dx.doi.org/10.3390/biomedicines10010022 |