Cargando…

Nrf2 in the Field of Dentistry with Special Attention to NLRP3

The aim of this review article was to summarize the functional implications of the nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2 (Nrf2), with special attention to the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domai...

Descripción completa

Detalles Bibliográficos
Autores principales: Schieffer, Lisa, Manzl, Claudia, Schatz, Christoph, Haybaeck, Johannes, Crismani, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772975/
https://www.ncbi.nlm.nih.gov/pubmed/35052653
http://dx.doi.org/10.3390/antiox11010149
_version_ 1784635970311684096
author Schieffer, Lisa
Manzl, Claudia
Schatz, Christoph
Haybaeck, Johannes
Crismani, Adriano
author_facet Schieffer, Lisa
Manzl, Claudia
Schatz, Christoph
Haybaeck, Johannes
Crismani, Adriano
author_sort Schieffer, Lisa
collection PubMed
description The aim of this review article was to summarize the functional implications of the nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2 (Nrf2), with special attention to the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domains-containing protein 3 (NLRP3) inflammasome in the field of dentistry. NLRP3 plays a crucial role in the progression of inflammatory and adaptive immune responses throughout the body. It is already known that this inflammasome is a key regulator of several systemic diseases. The initiation and activation of NLRP3 starts with the oral microbiome and its association with the pathogenesis and progression of several oral diseases, including periodontitis, periapical periodontitis, and oral squamous cell carcinoma (OSCC). The possible role of the inflammasome in oral disease conditions may involve the aberrant regulation of various response mechanisms, not only in the mouth but in the whole body. Understanding the cellular and molecular biology of the NLRP3 inflammasome and its relationship to Nrf2 is necessary for the rationale when suggesting it as a potential therapeutic target for treatment and prevention of oral inflammatory and immunological disorders. In this review, we highlighted the current knowledge about NLRP3, its likely role in the pathogenesis of various inflammatory oral processes, and its crosstalk with Nrf2, which might offer future possibilities for disease prevention and targeted therapy in the field of dentistry and oral health.
format Online
Article
Text
id pubmed-8772975
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87729752022-01-21 Nrf2 in the Field of Dentistry with Special Attention to NLRP3 Schieffer, Lisa Manzl, Claudia Schatz, Christoph Haybaeck, Johannes Crismani, Adriano Antioxidants (Basel) Review The aim of this review article was to summarize the functional implications of the nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2 (Nrf2), with special attention to the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domains-containing protein 3 (NLRP3) inflammasome in the field of dentistry. NLRP3 plays a crucial role in the progression of inflammatory and adaptive immune responses throughout the body. It is already known that this inflammasome is a key regulator of several systemic diseases. The initiation and activation of NLRP3 starts with the oral microbiome and its association with the pathogenesis and progression of several oral diseases, including periodontitis, periapical periodontitis, and oral squamous cell carcinoma (OSCC). The possible role of the inflammasome in oral disease conditions may involve the aberrant regulation of various response mechanisms, not only in the mouth but in the whole body. Understanding the cellular and molecular biology of the NLRP3 inflammasome and its relationship to Nrf2 is necessary for the rationale when suggesting it as a potential therapeutic target for treatment and prevention of oral inflammatory and immunological disorders. In this review, we highlighted the current knowledge about NLRP3, its likely role in the pathogenesis of various inflammatory oral processes, and its crosstalk with Nrf2, which might offer future possibilities for disease prevention and targeted therapy in the field of dentistry and oral health. MDPI 2022-01-12 /pmc/articles/PMC8772975/ /pubmed/35052653 http://dx.doi.org/10.3390/antiox11010149 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schieffer, Lisa
Manzl, Claudia
Schatz, Christoph
Haybaeck, Johannes
Crismani, Adriano
Nrf2 in the Field of Dentistry with Special Attention to NLRP3
title Nrf2 in the Field of Dentistry with Special Attention to NLRP3
title_full Nrf2 in the Field of Dentistry with Special Attention to NLRP3
title_fullStr Nrf2 in the Field of Dentistry with Special Attention to NLRP3
title_full_unstemmed Nrf2 in the Field of Dentistry with Special Attention to NLRP3
title_short Nrf2 in the Field of Dentistry with Special Attention to NLRP3
title_sort nrf2 in the field of dentistry with special attention to nlrp3
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772975/
https://www.ncbi.nlm.nih.gov/pubmed/35052653
http://dx.doi.org/10.3390/antiox11010149
work_keys_str_mv AT schiefferlisa nrf2inthefieldofdentistrywithspecialattentiontonlrp3
AT manzlclaudia nrf2inthefieldofdentistrywithspecialattentiontonlrp3
AT schatzchristoph nrf2inthefieldofdentistrywithspecialattentiontonlrp3
AT haybaeckjohannes nrf2inthefieldofdentistrywithspecialattentiontonlrp3
AT crismaniadriano nrf2inthefieldofdentistrywithspecialattentiontonlrp3