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Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations

Introduction: Sepsis is a serious and expensive healthcare problem, when caused by a multidrug-resistant (MDR) bacteria mortality and costs increase. A reduction in the time until the start of treatment improves clinical results. The objective is to perform a systematic review of economic evaluation...

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Autores principales: Rojas-Garcia, Paula, van der Pol, Simon, van Asselt, Antoinette D. I., Postma, Maarten J., Rodríguez-Ibeas, Roberto, Juárez-Castelló, Carmelo A., González, Marino, Antoñanzas, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773030/
https://www.ncbi.nlm.nih.gov/pubmed/35052904
http://dx.doi.org/10.3390/antibiotics11010027
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author Rojas-Garcia, Paula
van der Pol, Simon
van Asselt, Antoinette D. I.
Postma, Maarten J.
Rodríguez-Ibeas, Roberto
Juárez-Castelló, Carmelo A.
González, Marino
Antoñanzas, Fernando
author_facet Rojas-Garcia, Paula
van der Pol, Simon
van Asselt, Antoinette D. I.
Postma, Maarten J.
Rodríguez-Ibeas, Roberto
Juárez-Castelló, Carmelo A.
González, Marino
Antoñanzas, Fernando
author_sort Rojas-Garcia, Paula
collection PubMed
description Introduction: Sepsis is a serious and expensive healthcare problem, when caused by a multidrug-resistant (MDR) bacteria mortality and costs increase. A reduction in the time until the start of treatment improves clinical results. The objective is to perform a systematic review of economic evaluations to analyze the cost-effectiveness of diagnostic methods in sepsis and to draw lessons on the methods used to incorporate antimicrobial resistance (AMR) in these studies. Material and Methods: the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the Consolidated Health Economic Evaluation Reporting standards (CHEERS) checklist was used to extract the information from the texts. Results: A total of 16 articles were found. A decision model was performed in 14. We found two ways to handle resistance while modelling: the test could identify infections caused by a resistant pathogen or resistance-related inputs, or outcomes were included (the incidence of AMR in sepsis patients, antibiotic use, and infection caused by resistant bacterial pathogens). Conclusion: Using a diagnostic technique to detect sepsis early on is more cost-effective than standard care. Setting a direct relationship between the implementation of a testing strategy and the reduction of AMR cases, we made several assumptions about the efficacy of antibiotics and the length-of-stay of patients.
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spelling pubmed-87730302022-01-21 Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations Rojas-Garcia, Paula van der Pol, Simon van Asselt, Antoinette D. I. Postma, Maarten J. Rodríguez-Ibeas, Roberto Juárez-Castelló, Carmelo A. González, Marino Antoñanzas, Fernando Antibiotics (Basel) Review Introduction: Sepsis is a serious and expensive healthcare problem, when caused by a multidrug-resistant (MDR) bacteria mortality and costs increase. A reduction in the time until the start of treatment improves clinical results. The objective is to perform a systematic review of economic evaluations to analyze the cost-effectiveness of diagnostic methods in sepsis and to draw lessons on the methods used to incorporate antimicrobial resistance (AMR) in these studies. Material and Methods: the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the Consolidated Health Economic Evaluation Reporting standards (CHEERS) checklist was used to extract the information from the texts. Results: A total of 16 articles were found. A decision model was performed in 14. We found two ways to handle resistance while modelling: the test could identify infections caused by a resistant pathogen or resistance-related inputs, or outcomes were included (the incidence of AMR in sepsis patients, antibiotic use, and infection caused by resistant bacterial pathogens). Conclusion: Using a diagnostic technique to detect sepsis early on is more cost-effective than standard care. Setting a direct relationship between the implementation of a testing strategy and the reduction of AMR cases, we made several assumptions about the efficacy of antibiotics and the length-of-stay of patients. MDPI 2021-12-27 /pmc/articles/PMC8773030/ /pubmed/35052904 http://dx.doi.org/10.3390/antibiotics11010027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rojas-Garcia, Paula
van der Pol, Simon
van Asselt, Antoinette D. I.
Postma, Maarten J.
Rodríguez-Ibeas, Roberto
Juárez-Castelló, Carmelo A.
González, Marino
Antoñanzas, Fernando
Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
title Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
title_full Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
title_fullStr Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
title_full_unstemmed Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
title_short Diagnostic Testing for Sepsis: A Systematic Review of Economic Evaluations
title_sort diagnostic testing for sepsis: a systematic review of economic evaluations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773030/
https://www.ncbi.nlm.nih.gov/pubmed/35052904
http://dx.doi.org/10.3390/antibiotics11010027
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