Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation

Curcumin shows a broad spectrum of activities of relevance in the treatment of Alzheimer’s disease (AD); however, it is poorly absorbed and is also chemically and metabolically unstable, leading to a very low oral bioavailability. A small library of hybrid compounds designed as curcumin analogues an...

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Detalles Bibliográficos
Autores principales: Cores, Ángel, Carmona-Zafra, Noelia, Martín-Cámara, Olmo, Sánchez, Juan Domingo, Duarte, Pablo, Villacampa, Mercedes, Bermejo-Bescós, Paloma, Martín-Aragón, Sagrario, León, Rafael, Menéndez, J. Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773050/
https://www.ncbi.nlm.nih.gov/pubmed/35052532
http://dx.doi.org/10.3390/antiox11010028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773050/
https://www.ncbi.nlm.nih.gov/pubmed/35052532
http://dx.doi.org/10.3390/antiox11010028

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