Cargando…

Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis

Flavonoids and carotenoids are bioactive compounds that have protective effects against depressive symptoms. Flavonoids and carotenoids are the two main types of antioxidant phytochemicals. This study investigated the association between flavonoid and carotenoid intake and depressive symptoms in mid...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Seon-Joo, Jaiswal, Varun, Lee, Hae-Jeung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773076/
https://www.ncbi.nlm.nih.gov/pubmed/35052561
http://dx.doi.org/10.3390/antiox11010053
_version_ 1784635994274791424
author Park, Seon-Joo
Jaiswal, Varun
Lee, Hae-Jeung
author_facet Park, Seon-Joo
Jaiswal, Varun
Lee, Hae-Jeung
author_sort Park, Seon-Joo
collection PubMed
description Flavonoids and carotenoids are bioactive compounds that have protective effects against depressive symptoms. Flavonoids and carotenoids are the two main types of antioxidant phytochemicals. This study investigated the association between flavonoid and carotenoid intake and depressive symptoms in middle-aged Korean females. We analyzed the mechanism of these associations using an in silico method. Depressive symptoms were screened using the Beck Depression Inventory-II (BDI-II), and flavonoid and carotenoid intake were assessed using a semi-quantitative food frequency questionnaire. Using a multivariate logistic regression model, we found that flavones, anthocyanins, individual phenolic compounds, lycopene, and zeaxanthin were negatively associated with depressive symptoms. In silico analysis showed that most flavonoids have high docking scores for monoamine oxidase A (MAOA) and monoamine oxidase B (MAOB), which are two important drug targets in depression. The results of the docking of brain-derived neurotrophic factor (BDNF) and carotenoids suggested the possibility of allosteric activation of BDNF by carotenoids. These results suggest that dietary flavonoids and carotenoids can be utilized in the treatment of depressive symptoms.
format Online
Article
Text
id pubmed-8773076
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87730762022-01-21 Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis Park, Seon-Joo Jaiswal, Varun Lee, Hae-Jeung Antioxidants (Basel) Article Flavonoids and carotenoids are bioactive compounds that have protective effects against depressive symptoms. Flavonoids and carotenoids are the two main types of antioxidant phytochemicals. This study investigated the association between flavonoid and carotenoid intake and depressive symptoms in middle-aged Korean females. We analyzed the mechanism of these associations using an in silico method. Depressive symptoms were screened using the Beck Depression Inventory-II (BDI-II), and flavonoid and carotenoid intake were assessed using a semi-quantitative food frequency questionnaire. Using a multivariate logistic regression model, we found that flavones, anthocyanins, individual phenolic compounds, lycopene, and zeaxanthin were negatively associated with depressive symptoms. In silico analysis showed that most flavonoids have high docking scores for monoamine oxidase A (MAOA) and monoamine oxidase B (MAOB), which are two important drug targets in depression. The results of the docking of brain-derived neurotrophic factor (BDNF) and carotenoids suggested the possibility of allosteric activation of BDNF by carotenoids. These results suggest that dietary flavonoids and carotenoids can be utilized in the treatment of depressive symptoms. MDPI 2021-12-27 /pmc/articles/PMC8773076/ /pubmed/35052561 http://dx.doi.org/10.3390/antiox11010053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Seon-Joo
Jaiswal, Varun
Lee, Hae-Jeung
Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis
title Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis
title_full Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis
title_fullStr Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis
title_full_unstemmed Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis
title_short Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis
title_sort dietary intake of flavonoids and carotenoids is associated with anti-depressive symptoms: epidemiological study and in silico—mechanism analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773076/
https://www.ncbi.nlm.nih.gov/pubmed/35052561
http://dx.doi.org/10.3390/antiox11010053
work_keys_str_mv AT parkseonjoo dietaryintakeofflavonoidsandcarotenoidsisassociatedwithantidepressivesymptomsepidemiologicalstudyandinsilicomechanismanalysis
AT jaiswalvarun dietaryintakeofflavonoidsandcarotenoidsisassociatedwithantidepressivesymptomsepidemiologicalstudyandinsilicomechanismanalysis
AT leehaejeung dietaryintakeofflavonoidsandcarotenoidsisassociatedwithantidepressivesymptomsepidemiologicalstudyandinsilicomechanismanalysis