A Conserved uORF Regulates APOBEC3G Translation and Is Targeted by HIV-1 Vif Protein to Repress the Antiviral Factor

The HIV-1 Vif protein is essential for viral fitness and pathogenicity. Vif decreases expression of cellular restriction factors APOBEC3G (A3G), A3F, A3D and A3H, which inhibit HIV-1 replication by inducing hypermutation during reverse transcription. Vif counteracts A3G at several levels (transcript...

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Detalles Bibliográficos
Autores principales: Libre, Camille, Seissler, Tanja, Guerrero, Santiago, Batisse, Julien, Verriez, Cédric, Stupfler, Benjamin, Gilmer, Orian, Cabrera-Rodriguez, Romina, Weber, Melanie M., Valenzuela-Fernandez, Agustin, Cimarelli, Andrea, Etienne, Lucie, Marquet, Roland, Paillart, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773096/
https://www.ncbi.nlm.nih.gov/pubmed/35052693
http://dx.doi.org/10.3390/biomedicines10010013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773096/
https://www.ncbi.nlm.nih.gov/pubmed/35052693
http://dx.doi.org/10.3390/biomedicines10010013

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