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Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies
Gestational diabetes mellitus (GDM) is characterized by a set of metabolic complications arising from adaptive failures to the pregnancy period. Estimates point to a prevalence of 3 to 15% of pregnancies. Its etiology includes intrinsic and extrinsic aspects of the progenitress, which may contribute...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773111/ https://www.ncbi.nlm.nih.gov/pubmed/35052633 http://dx.doi.org/10.3390/antiox11010129 |
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author | de Mendonça, Elaine Luiza Santos Soares Fragoso, Marilene Brandão Tenório de Oliveira, Jerusa Maria Xavier, Jadriane Almeida Goulart, Marília Oliveira Fonseca de Oliveira, Alane Cabral Menezes |
author_facet | de Mendonça, Elaine Luiza Santos Soares Fragoso, Marilene Brandão Tenório de Oliveira, Jerusa Maria Xavier, Jadriane Almeida Goulart, Marília Oliveira Fonseca de Oliveira, Alane Cabral Menezes |
author_sort | de Mendonça, Elaine Luiza Santos Soares |
collection | PubMed |
description | Gestational diabetes mellitus (GDM) is characterized by a set of metabolic complications arising from adaptive failures to the pregnancy period. Estimates point to a prevalence of 3 to 15% of pregnancies. Its etiology includes intrinsic and extrinsic aspects of the progenitress, which may contribute to the pathophysiogenesis of GDM. Recently, researchers have identified that inflammation, oxidative stress, and the gut microbiota participate in the development of the disease, with potentially harmful effects on the health of the maternal-fetal binomial, in the short and long terms. In this context, alternative therapies were investigated from two perspectives: the modulation of the intestinal microbiota, with probiotics and prebiotics, and the use of natural products with antioxidant and anti-inflammatory properties, which may mitigate the endogenous processes of the GDM, favoring the health of the mother and her offspring, and in a future perspective, alleviating this critical public health problem. |
format | Online Article Text |
id | pubmed-8773111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87731112022-01-21 Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies de Mendonça, Elaine Luiza Santos Soares Fragoso, Marilene Brandão Tenório de Oliveira, Jerusa Maria Xavier, Jadriane Almeida Goulart, Marília Oliveira Fonseca de Oliveira, Alane Cabral Menezes Antioxidants (Basel) Review Gestational diabetes mellitus (GDM) is characterized by a set of metabolic complications arising from adaptive failures to the pregnancy period. Estimates point to a prevalence of 3 to 15% of pregnancies. Its etiology includes intrinsic and extrinsic aspects of the progenitress, which may contribute to the pathophysiogenesis of GDM. Recently, researchers have identified that inflammation, oxidative stress, and the gut microbiota participate in the development of the disease, with potentially harmful effects on the health of the maternal-fetal binomial, in the short and long terms. In this context, alternative therapies were investigated from two perspectives: the modulation of the intestinal microbiota, with probiotics and prebiotics, and the use of natural products with antioxidant and anti-inflammatory properties, which may mitigate the endogenous processes of the GDM, favoring the health of the mother and her offspring, and in a future perspective, alleviating this critical public health problem. MDPI 2022-01-07 /pmc/articles/PMC8773111/ /pubmed/35052633 http://dx.doi.org/10.3390/antiox11010129 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Mendonça, Elaine Luiza Santos Soares Fragoso, Marilene Brandão Tenório de Oliveira, Jerusa Maria Xavier, Jadriane Almeida Goulart, Marília Oliveira Fonseca de Oliveira, Alane Cabral Menezes Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies |
title | Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies |
title_full | Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies |
title_fullStr | Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies |
title_full_unstemmed | Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies |
title_short | Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies |
title_sort | gestational diabetes mellitus: the crosslink among inflammation, nitroxidative stress, intestinal microbiota and alternative therapies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773111/ https://www.ncbi.nlm.nih.gov/pubmed/35052633 http://dx.doi.org/10.3390/antiox11010129 |
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