Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer

To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for...

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Autores principales: Fedotova, Maria K., Usachev, Maksim N., Bogdanova, Ekaterina V., Diachkova, Ekaterina, Vasil’ev, Yuriy, Bregadze, Vladimir I., Mironov, Andrey F., Grin, Mikhail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773115/
https://www.ncbi.nlm.nih.gov/pubmed/35049714
http://dx.doi.org/10.3390/bioengineering9010005
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author Fedotova, Maria K.
Usachev, Maksim N.
Bogdanova, Ekaterina V.
Diachkova, Ekaterina
Vasil’ev, Yuriy
Bregadze, Vladimir I.
Mironov, Andrey F.
Grin, Mikhail A.
author_facet Fedotova, Maria K.
Usachev, Maksim N.
Bogdanova, Ekaterina V.
Diachkova, Ekaterina
Vasil’ev, Yuriy
Bregadze, Vladimir I.
Mironov, Andrey F.
Grin, Mikhail A.
author_sort Fedotova, Maria K.
collection PubMed
description To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities.
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spelling pubmed-87731152022-01-21 Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer Fedotova, Maria K. Usachev, Maksim N. Bogdanova, Ekaterina V. Diachkova, Ekaterina Vasil’ev, Yuriy Bregadze, Vladimir I. Mironov, Andrey F. Grin, Mikhail A. Bioengineering (Basel) Communication To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities. MDPI 2021-12-25 /pmc/articles/PMC8773115/ /pubmed/35049714 http://dx.doi.org/10.3390/bioengineering9010005 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Fedotova, Maria K.
Usachev, Maksim N.
Bogdanova, Ekaterina V.
Diachkova, Ekaterina
Vasil’ev, Yuriy
Bregadze, Vladimir I.
Mironov, Andrey F.
Grin, Mikhail A.
Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
title Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
title_full Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
title_fullStr Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
title_full_unstemmed Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
title_short Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
title_sort highly purified conjugates of natural chlorin with cobalt bis(dicarbollide) nanoclusters for pdt and bnct therapy of cancer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773115/
https://www.ncbi.nlm.nih.gov/pubmed/35049714
http://dx.doi.org/10.3390/bioengineering9010005
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