Cargando…

Investigation of Leoligin Derivatives as NF-κΒ Inhibitory Agents

The transcription factor NF-κB is an essential mediator of inflammation; thus, the identification of compounds that interfere with the NF-κB signaling pathway is an important topic. The natural products leoligin and 5-methoxyleoligin have served as a starting point for the development of NF-κB inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Linder, Thomas, Papaplioura, Eleni, Ogurlu, Diyana, Geyrhofer, Sophie, Hummelbrunner, Scarlet, Schachner, Daniel, Atanasov, Atanas G., Mihovilovic, Marko D., Dirsch, Verena M., Schnürch, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773117/ https://www.ncbi.nlm.nih.gov/pubmed/35052742 http://dx.doi.org/10.3390/biomedicines10010062

Ejemplares similares

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease
por: Linder, Thomas, et al.
Publicado: (2019)

Design and Synthesis of a Compound Library Exploiting 5-Methoxyleoligin as Potential Cholesterol Efflux Promoter
por: Linder, Thomas, et al.
Publicado: (2020)

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages
por: Wang, Limei, et al.
Publicado: (2016)

Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts
por: Reisinger, Ute, et al.
Publicado: (2009)

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes
por: Dao-Huy, Toan, et al.
Publicado: (2020)

Linked magnolol dimer as a selective PPARγ agonist – Structure-based rational design, synthesis, and bioactivity evaluation
por: Dreier, Dominik, et al.
Publicado: (2017)

Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein
por: Duwensee, Kristina, et al.
Publicado: (2011)

Resveratrol inhibits migration and Rac1 activation in EGF- but not PDGF-activated vascular smooth muscle cells
por: Kumerz, Mario, et al.
Publicado: (2011)

Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation
por: Rycek, Lukas, et al.
Publicado: (2018)

NF-κB Inhibitors from Eurycoma longifolia
por: Tran, Thi Van Anh, et al.
Publicado: (2014)

One-pot synthesis of triazines as potential agents affecting cell differentiation
por: Linder, Thomas, et al.
Publicado: (2018)

C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling
por: Pan, San-Po, et al.
Publicado: (2019)

Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
por: Heiss, Elke H., et al.
Publicado: (2014)

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes
por: Suryavanshi, Sachin V., et al.
Publicado: (2017)

A Biochemometric Approach for the Identification of In Vitro Anti-Inflammatory Constituents in Masterwort
por: Zwirchmayr, Julia, et al.
Publicado: (2020)

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status
por: Ladurner, Angela, et al.
Publicado: (2012)

Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level
por: Malainer, Clemens, et al.
Publicado: (2017)

Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway
por: Triantafyllou, Eleni-Anastasia, et al.
Publicado: (2019)

Magnolol dimer-derived fragments as PPARγ-selective probes
por: Dreier, Dominik, et al.
Publicado: (2018)

Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: Assessing the activity of flavonoids from the stem bark of Oroxylum indicum
por: Tran, Thi Van Anh, et al.
Publicado: (2015)

MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition
por: Fujikura, Tomoyuki, et al.
Publicado: (2018)

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo
por: Liu, Rongxia, et al.
Publicado: (2017)

Kanglaite inhibits EMT caused by TNF-α via NF-κΒ inhibition in colorectal cancer cells
por: Shi, Guiling, et al.
Publicado: (2017)

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
por: Wang, Yijia, et al.
Publicado: (2017)

Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-κΒ
por: Hwang, Soonjae, et al.
Publicado: (2019)

Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner
por: Schreiner, Cornelia E., et al.
Publicado: (2011)

Natural products in drug discovery: advances and opportunities
por: Atanasov, Atanas G., et al.
Publicado: (2021)

3D micro-environment regulates NF-κβ dependent adhesion to induce monocyte differentiation
por: Bhattacharya, Anindita, et al.
Publicado: (2018)

Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF- κ B Inhibitors
por: Liu, Xin, et al.
Publicado: (2017)

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
por: Marazioti, Antonia, et al.
Publicado: (2018)

Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-κβ and caspase-3
por: Abdel-Wahab, Basel A., et al.
Publicado: (2014)

Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin
por: Khalil, Mohammed N. A., et al.
Publicado: (2019)

1-Methyl-D-tryptophan Reduces Tumor CD133(+) cells, Wnt/β-catenin and NF-κβp65 while Enhances Lymphocytes NF-κβ2, STAT3, and STAT4 Pathways in Murine Pancreatic Adenocarcinoma
por: Alahdal, Murad, et al.
Publicado: (2018)

Direct Functionalization of (Un)protected Tetrahydroisoquinoline and Isochroman under Iron and Copper Catalysis: Two Metals, Two Mechanisms
por: Ghobrial, Michael, et al.
Publicado: (2011)

Exploration of C–H and N–H-bond functionalization towards 1-(1,2-diarylindol-3-yl)tetrahydroisoquinolines
por: Ghobrial, Michael, et al.
Publicado: (2014)

Aryl Bromides and Aryl Chlorides for the Direct Arylation of Benzylic Amines Mediated by Ruthenium(II)
por: Dastbaravardeh, Navid, et al.
Publicado: (2013)

Author Correction: Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
por: Wang, Yijia, et al.
Publicado: (2018)

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation
por: Liu, Rongxia, et al.
Publicado: (2015)

Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα
por: Hu, Yani, et al.
Publicado: (2017)

Chrysin ameliorates STZ-induced diabetes in rats: possible impact of modulation of TLR4/NF-κβ pathway
por: Salama, Abeer, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ptf4j0qhoslemlq186ovl1r6n1