Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy

Cefiderocol use in A. baumannii pneumonia still represents an important matter of debate. The aim of this study is to describe 13 cases of carbapenem-resistant A. baumannii (CRAB) pneumonia treated with cefiderocol in real-life practice. We retrospectively included patients with CRAB pneumonia hospi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rando, Emanuele, Segala, Francesco Vladimiro, Vargas, Joel, Seguiti, Cristina, De Pascale, Gennaro, Murri, Rita, Fantoni, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773286/
https://www.ncbi.nlm.nih.gov/pubmed/35052880
http://dx.doi.org/10.3390/antibiotics11010003
_version_ 1784636046757068800
author Rando, Emanuele
Segala, Francesco Vladimiro
Vargas, Joel
Seguiti, Cristina
De Pascale, Gennaro
Murri, Rita
Fantoni, Massimo
author_facet Rando, Emanuele
Segala, Francesco Vladimiro
Vargas, Joel
Seguiti, Cristina
De Pascale, Gennaro
Murri, Rita
Fantoni, Massimo
author_sort Rando, Emanuele
collection PubMed
description Cefiderocol use in A. baumannii pneumonia still represents an important matter of debate. The aim of this study is to describe 13 cases of carbapenem-resistant A. baumannii (CRAB) pneumonia treated with cefiderocol in real-life practice. We retrospectively included patients with CRAB pneumonia hospitalized at Fondazione Policlinico Universitario Agostino Gemelli Hospital treated with cefiderocol either in the general ward or the intensive care unit. A total of 11 patients out of 13 had ventilator-associated pneumonia caused by CRAB, and 12/13 patients had polymicrobial infection. We found a 30-day success rate of 54%. Cefiderocol may have a role when facing severe XDR A. baumannii pneumonia. Future studies are warranted to better define its place in therapy in CRAB infections.
format Online
Article
Text
id pubmed-8773286
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87732862022-01-21 Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy Rando, Emanuele Segala, Francesco Vladimiro Vargas, Joel Seguiti, Cristina De Pascale, Gennaro Murri, Rita Fantoni, Massimo Antibiotics (Basel) Brief Report Cefiderocol use in A. baumannii pneumonia still represents an important matter of debate. The aim of this study is to describe 13 cases of carbapenem-resistant A. baumannii (CRAB) pneumonia treated with cefiderocol in real-life practice. We retrospectively included patients with CRAB pneumonia hospitalized at Fondazione Policlinico Universitario Agostino Gemelli Hospital treated with cefiderocol either in the general ward or the intensive care unit. A total of 11 patients out of 13 had ventilator-associated pneumonia caused by CRAB, and 12/13 patients had polymicrobial infection. We found a 30-day success rate of 54%. Cefiderocol may have a role when facing severe XDR A. baumannii pneumonia. Future studies are warranted to better define its place in therapy in CRAB infections. MDPI 2021-12-21 /pmc/articles/PMC8773286/ /pubmed/35052880 http://dx.doi.org/10.3390/antibiotics11010003 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Rando, Emanuele
Segala, Francesco Vladimiro
Vargas, Joel
Seguiti, Cristina
De Pascale, Gennaro
Murri, Rita
Fantoni, Massimo
Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy
title Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy
title_full Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy
title_fullStr Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy
title_full_unstemmed Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy
title_short Cefiderocol for Severe Carbapenem-Resistant A. baumannii Pneumonia: Towards the Comprehension of Its Place in Therapy
title_sort cefiderocol for severe carbapenem-resistant a. baumannii pneumonia: towards the comprehension of its place in therapy
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773286/
https://www.ncbi.nlm.nih.gov/pubmed/35052880
http://dx.doi.org/10.3390/antibiotics11010003
work_keys_str_mv AT randoemanuele cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy
AT segalafrancescovladimiro cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy
AT vargasjoel cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy
AT seguiticristina cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy
AT depascalegennaro cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy
AT murririta cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy
AT fantonimassimo cefiderocolforseverecarbapenemresistantabaumanniipneumoniatowardsthecomprehensionofitsplaceintherapy

Ejemplares similares