BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

KELCH-ECH-associated protein 1 (KEAP1) is an adaptor protein of Cullin 3 (CUL3) E3 ubiquitin ligase that targets a redox sensitive transcription factor, NF-E2-related factor 2 (NRF2). BRCA1-associated protein 1 (BAP1) is a tumor suppressor and deubiquitinase whose mutations increase the risk of seve...

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Detalles Bibliográficos
Autores principales: Kang, Jong-Su, Nam, Le Ba, Yoo, Ok-Kyung, Lee, Kyeong, Suh, Young-Ah, Kim, Dalyong, Kim, Woo Kyung, Lim, Chi-Yeon, Lee, Haeseung, Keum, Young-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773298/
https://www.ncbi.nlm.nih.gov/pubmed/35052618
http://dx.doi.org/10.3390/antiox11010114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773298/
https://www.ncbi.nlm.nih.gov/pubmed/35052618
http://dx.doi.org/10.3390/antiox11010114

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