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Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma

Diabetes mellitus renders patients susceptible to chronic wounds and various infections. Regarding the latter, fungal infections are of particular concern since, although they are the source of significant morbidity and mortality in immunocompromised patients, they are generally resistant to convent...

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Autores principales: Choi, Kyu Young, Sultan, Md. Tipu, Ajiteru, Olatunji, Hong, Heesun, Lee, Young Jin, Lee, Ji Seung, Lee, Hanna, Lee, Ok Joo, Kim, Soon Hee, Lee, Joong Seob, Park, Sung-Jin, Eden, James Gary, Park, Chan Hum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773309/
https://www.ncbi.nlm.nih.gov/pubmed/35052706
http://dx.doi.org/10.3390/biomedicines10010027
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author Choi, Kyu Young
Sultan, Md. Tipu
Ajiteru, Olatunji
Hong, Heesun
Lee, Young Jin
Lee, Ji Seung
Lee, Hanna
Lee, Ok Joo
Kim, Soon Hee
Lee, Joong Seob
Park, Sung-Jin
Eden, James Gary
Park, Chan Hum
author_facet Choi, Kyu Young
Sultan, Md. Tipu
Ajiteru, Olatunji
Hong, Heesun
Lee, Young Jin
Lee, Ji Seung
Lee, Hanna
Lee, Ok Joo
Kim, Soon Hee
Lee, Joong Seob
Park, Sung-Jin
Eden, James Gary
Park, Chan Hum
author_sort Choi, Kyu Young
collection PubMed
description Diabetes mellitus renders patients susceptible to chronic wounds and various infections. Regarding the latter, fungal infections are of particular concern since, although they are the source of significant morbidity and mortality in immunocompromised patients, they are generally resistant to conventional treatment and a definite treatment strategy has not yet been established. Herein, we report the treatment of skin wounds in a diabetic rat model, infected by Candida albicans, with low temperature helium plasma generated in a hand-held atmospheric jet device. A fungal infection was induced on two dorsal skin wounds of the diabetic rats, and one wound was treated with the plasma jet whereas the other served as a control. Histological analysis revealed accelerated skin wound healing and decreased evidence of fungal infection in the plasma-treated group, as compared to the control group. Regeneration of the epidermis and dermis, collagen deposition, and neovascularization were all observed as a result of plasma treatment, but without wound contraction, scar formation or any evidence of thermal damage to the tissue. These findings demonstrate that the He plasma jet is remarkably effective in diabetic skin wounds infected by Candida albicans, thereby providing a promising medical treatment option for diabetes mellitus patients with skin wound and fungal infections.
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spelling pubmed-87733092022-01-21 Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma Choi, Kyu Young Sultan, Md. Tipu Ajiteru, Olatunji Hong, Heesun Lee, Young Jin Lee, Ji Seung Lee, Hanna Lee, Ok Joo Kim, Soon Hee Lee, Joong Seob Park, Sung-Jin Eden, James Gary Park, Chan Hum Biomedicines Article Diabetes mellitus renders patients susceptible to chronic wounds and various infections. Regarding the latter, fungal infections are of particular concern since, although they are the source of significant morbidity and mortality in immunocompromised patients, they are generally resistant to conventional treatment and a definite treatment strategy has not yet been established. Herein, we report the treatment of skin wounds in a diabetic rat model, infected by Candida albicans, with low temperature helium plasma generated in a hand-held atmospheric jet device. A fungal infection was induced on two dorsal skin wounds of the diabetic rats, and one wound was treated with the plasma jet whereas the other served as a control. Histological analysis revealed accelerated skin wound healing and decreased evidence of fungal infection in the plasma-treated group, as compared to the control group. Regeneration of the epidermis and dermis, collagen deposition, and neovascularization were all observed as a result of plasma treatment, but without wound contraction, scar formation or any evidence of thermal damage to the tissue. These findings demonstrate that the He plasma jet is remarkably effective in diabetic skin wounds infected by Candida albicans, thereby providing a promising medical treatment option for diabetes mellitus patients with skin wound and fungal infections. MDPI 2021-12-23 /pmc/articles/PMC8773309/ /pubmed/35052706 http://dx.doi.org/10.3390/biomedicines10010027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Kyu Young
Sultan, Md. Tipu
Ajiteru, Olatunji
Hong, Heesun
Lee, Young Jin
Lee, Ji Seung
Lee, Hanna
Lee, Ok Joo
Kim, Soon Hee
Lee, Joong Seob
Park, Sung-Jin
Eden, James Gary
Park, Chan Hum
Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
title Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
title_full Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
title_fullStr Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
title_full_unstemmed Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
title_short Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
title_sort treatment of fungal-infected diabetic wounds with low temperature plasma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773309/
https://www.ncbi.nlm.nih.gov/pubmed/35052706
http://dx.doi.org/10.3390/biomedicines10010027
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